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Immunological stimulation for the treatment of leishmaniasis: A modality worthy of serious consideration

Musa, Ahmed Mudawi ; Noazin, Sassan ; Khalil, E.A.G. ; Modabber, Farrokh

In: Transactions of The Royal Society of Tropical Medicine and Hygiene, 2010, vol. 104, no. 1, p. 1-2

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    Titel
    • Immunological stimulation for the treatment of leishmaniasis: A modality worthy of serious consideration
    Autor
    • Musa, Ahmed Mudawi. Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan
    • Noazin, Sassan. World Health Organization, 1211 Geneva 27, Switzerland
    • Khalil, E.A.G.. Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan
    • Modabber, Farrokh. Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan
    Dokumententyp
    • Postprint
    Sprache
    • Englisch
    Veröffentlicht in
    • Transactions of The Royal Society of Tropical Medicine and Hygiene, 2010, vol. 104, no. 1, p. 1-2. Royal Society of Tropical Medicine and Hygiene
    Andere elektronische Ausgabe
    OAI-PMH-ID
    • oai:doc.rero.ch:293034
    Summary
    Instead of relying on drugs to reduce the parasite burden of leishmaniasis, and waiting for the effector immune response to develop in time to control the parasites, immunotherapy in conjunction with chemotherapy can rapidly induce the effector immune response. With a safe and potent drug plus an affordable therapeutic vaccine (immunostimulant), which remains to be developed, a single visit by patients with visceral or cutaneous leishmaniasis might be sufficient to induce a quick and lasting recovery. Drug toxicity and the emergence of resistance could also be dramatically reduced compared with present long-term monotherapy. Immunotherapy could be an effective addition to chemotherapy for leishmaniasis