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Challenging Recommended Oral and Intravenous Voriconazole Doses for Improved Efficacy and Safety: Population Pharmacokinetics-Based Analysis of Adult Patients With Invasive Fungal Infections

Pascual, Andres ; Csajka, Chantal ; Buclin, Thierry ; Bolay, Saskia ; Bille, Jacques ; Calandra, Thierry ; Marchetti, Oscar

In: Clinical Infectious Diseases, 2012, vol. 55, no. 3, p. 381-390

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    Titel
    • Challenging Recommended Oral and Intravenous Voriconazole Doses for Improved Efficacy and Safety: Population Pharmacokinetics-Based Analysis of Adult Patients With Invasive Fungal Infections
    Autor
    • Pascual, Andres. Infectious Diseases Service
    • Csajka, Chantal. Division of Clinical Pharmacology and Toxicology, Department of Medicine
    • Buclin, Thierry. Division of Clinical Pharmacology and Toxicology, Department of Medicine
    • Bolay, Saskia. Infectious Diseases Service
    • Bille, Jacques. Institute of Microbiology, Centre Hospitalier Universitaire Vaudois, University of Lausanne
    • Calandra, Thierry. Infectious Diseases Service
    • Marchetti, Oscar. Infectious Diseases Service
    Dokumententyp
    • Postprint
    Sprache
    • Englisch
    Veröffentlicht in
    • Clinical Infectious Diseases, 2012, vol. 55, no. 3, p. 381-390. Oxford University Press
    Andere elektronische Ausgabe
    Klassifikation
    • Gesundheit
    OAI-PMH-ID
    • oai:doc.rero.ch:292976
    Summary
    This population-pharmacokinetics analysis involving adult patients with invasive fungal infections challenges recommended voriconazole dosing regimens. Higher oral than intravenous doses, followed by individualized adjustments based on therapeutic drug monitoring, are needed to improve achievement of the therapeutic target for maximizing response by minimizing neurotoxicity