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Environmentally Relevant Concentrations of 17α-Ethinylestradiol (EE2) Interfere With the Growth Hormone (GH)/Insulin-Like Growth Factor (IGF)-I System in Developing Bony Fish

Shved, Natallia ; Berishvili, Giorgi ; Baroiller, Jean-François ; Segner, Helmut ; Reinecke, Manfred

In: Toxicological Sciences, 2008, vol. 106, no. 1, p. 93-102

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    Titre
    • Environmentally Relevant Concentrations of 17α-Ethinylestradiol (EE2) Interfere With the Growth Hormone (GH)/Insulin-Like Growth Factor (IGF)-I System in Developing Bony Fish
    Auteur
    • Shved, Natallia. Division of Neuroendocrinology, Institute of Anatomy, University of Zürich, Winterthurerstr 190, CH-8057 Zürich, Switzerland
    • Berishvili, Giorgi. Division of Neuroendocrinology, Institute of Anatomy, University of Zürich, Winterthurerstr 190, CH-8057 Zürich, Switzerland
    • Baroiller, Jean-François. Centre de Coopération Internationale en Recherche Agronomique pour le Développement-Elevage et Médecine Vétérinaire Tropicale, Unité Propre de Recherché 20, 34398 Montpellier, France
    • Segner, Helmut. Centre for Fish and Wildlife Health, University of Bern, Länggass-Str 122, CH-3001 Bern, Switzerland
    • Reinecke, Manfred. Division of Neuroendocrinology, Institute of Anatomy, University of Zürich, Winterthurerstr 190, CH-8057 Zürich, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Toxicological Sciences, 2008, vol. 106, no. 1, p. 93-102. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:292593
    Summary
    The aim of this study was to evaluate whether effects of environmental estrogens on fish growth and reproduction may be mediated via modulating the growth hormone (GH)/insulin-like growth factor I (IGF-I) system. To this end, developing male and female monosex populations of tilapia were exposed to 17α-ethinylestradiol (EE2) at 5 and 25 ng EE2/l water from 10-day postfertilization (DPF) until 100 DPF. Under exposure to both EE2 concentrations, sex ratio shifted toward more females and body length, and weight were significantly reduced in males. The growth-reducing effect was associated with significant changes in hepatic IGF-I expression, both in males and females and with significant alterations of IGF-I mRNA and GH mRNA in the brain. The changes in IGF-I and GH mRNA were accompanied by altered estrogen receptor α (ERα) expression in brain and liver. These findings point to an influence of estrogenic exposure on the endocrine GH/IGF-I axis. In addition, the EE2 treatment resulted in significant changes of ERα and IGF-I expression in ovaries and testis, suggesting that the estrogens interact not only with the endocrine but also with the autocrine/paracrine part of the IGF-I system. Overall, our results provide evidence that EE2 at environmentally relevant concentrations is able to interfere with the GH/IGF-I system in bony fish and that the impairing effects of estrogens reported on fish growth and reproductive functions may rather result from a cross talk between the sex steroid and the IGF-I system than be toxicological