Fulltext

Antithrombin activity in children with chylothorax

Bernet-Buettiker, Vera ; Waldvogel, Katharina ; Cannizzaro, Vincenzo ; Albisetti, Manuela

In: European Journal of Cardio-Thoracic Surgery, 2006, vol. 29, no. 3, p. 406-409

Zum persönliche Liste hinzufügen
    Titel
    • Antithrombin activity in children with chylothorax
    Autor
    • Bernet-Buettiker, Vera. Division of Neonatology and Intensive Care, University Children's Hospital, Steinwiesstrasse 75, CH-8032 Zurich, Switzerland
    • Waldvogel, Katharina. Division of Neonatology and Intensive Care, University Children's Hospital, Steinwiesstrasse 75, CH-8032 Zurich, Switzerland
    • Cannizzaro, Vincenzo. Division of Neonatology and Intensive Care, University Children's Hospital, Steinwiesstrasse 75, CH-8032 Zurich, Switzerland
    • Albisetti, Manuela. Division of Hematology, University Children's Hospital, Steinwiesstrasse 75, CH-8032 Zurich, Switzerland
    Dokumententyp
    • Postprint
    Sprache
    • Englisch
    Veröffentlicht in
    • European Journal of Cardio-Thoracic Surgery, 2006, vol. 29, no. 3, p. 406-409. Elsevier Science B.V.
    Andere elektronische Ausgabe
    OAI-PMH-ID
    • oai:doc.rero.ch:292057
    Summary
    Objective: To determine whether increased antithrombin loss is present in children with chylothorax after cardiac surgery. Methods: Plasma and pleural effusion samples of children with chylous and non-chylous pleural effusion were assayed for antithrombin activity. Results: Ten children with chylothorax and five children with non-chylous pleural effusion were investigated. There was statistically significant increase in mean antithrombin activity in chylous samples (32.2 ± 11.4%) compared to non-chylous samples (14.4 ± 13.9%), and significant decrease in plasma of children with chylothorax (44.6 ± 15.4%) compared to children with non-chylous pleural effusion (69.9 ± 22.4%). Seven of 10 children with chylous and none of the children without chylous developed thrombosis (p < 0.007). Conclusions: Increased loss of antithrombin is present in children with chylothorax, potentially predisposing these children to an increased risk of thrombosis. Repeated antithrombin substitution should be considered in critically ill children with chylothorax