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Fast-Twitch Glycolytic Skeletal Muscle Is Predisposed to Age-Induced Impairments in Mitochondrial Function

Jacobs, Robert A. ; Díaz, Víctor ; Soldini, Lavinia ; Haider, Thomas ; Thomassen, Martin ; Nordsborg, Nikolai B. ; Gassmann, Max ; Lundby, Carsten

In: Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences, 2013, vol. 68, no. 9, p. 1010-1022

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    Titre
    • Fast-Twitch Glycolytic Skeletal Muscle Is Predisposed to Age-Induced Impairments in Mitochondrial Function
    Auteur
    • Jacobs, Robert A.. Zurich Center for Integrative Human Physiology (ZIHP) and
    • Díaz, Víctor. Zurich Center for Integrative Human Physiology (ZIHP) and
    • Soldini, Lavinia. Institute of Physiology, University of Zurich, Switzerland.
    • Haider, Thomas. Institute of Veterinary Physiology, Vetsuisse Faculty, University of Zurich, Switzerland.
    • Thomassen, Martin. Department of Exercise and Sport Sciences, University of Copenhagen, Denmark.
    • Nordsborg, Nikolai B.. Department of Exercise and Sport Sciences, University of Copenhagen, Denmark.
    • Gassmann, Max. Zurich Center for Integrative Human Physiology (ZIHP) and
    • Lundby, Carsten. Zurich Center for Integrative Human Physiology (ZIHP) and
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences, 2013, vol. 68, no. 9, p. 1010-1022. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:291917
    Summary
    The etiology of mammalian senescence is suggested to involve the progressive impairment of mitochondrial function; however, direct observations of age-induced alterations in actual respiratory chain function are lacking. Accordingly, we assessed mitochondrial function via high-resolution respirometry and mitochondrial protein expression in soleus, quadricep, and lateral gastrocnemius skeletal muscles, which represent type 1 slow-twitch oxidative muscle (soleus) and type 2 fast-twitch glycolytic muscle (quadricep and gastrocnemius), respectively, in young (10-12 weeks) and mature (74-76 weeks) mice. Electron transport through mitochondrial complexes I and III increases with age in quadricep and gastrocnemius, which is not observed in soleus. Mitochondrial coupling efficiency during respiration through complex I also deteriorates with age in gastrocnemius and shows a tendency (p = .085) to worsen in quadricep. These data demonstrate actual alterations in electron transport function that occurs with age and are dependent on skeletal muscle type