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The role of transcription factories-mediated interchromosomal contacts in the organization of nuclear architecture

Dorier, Julien ; Stasiak, Andrzej

In: Nucleic Acids Research, 2010, vol. 38, no. 21, p. 7410-7421

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    Titel
    • The role of transcription factories-mediated interchromosomal contacts in the organization of nuclear architecture
    Autor
    • Dorier, Julien. Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, 1015-Lausanne, Switzerland
    • Stasiak, Andrzej. E-mail: andrzej.stasiak@unil.ch
    Dokumententyp
    • Postprint
    Sprache
    • Englisch
    Veröffentlicht in
    • Nucleic Acids Research, 2010, vol. 38, no. 21, p. 7410-7421. Oxford University Press
    Andere elektronische Ausgabe
    OAI-PMH-ID
    • oai:doc.rero.ch:291792
    Summary
    Using numerical simulations, we investigate the underlying physical effects responsible for the overall organization of chromosomal territories in interphase nuclei. In particular, we address the following three questions: (i) why are chromosomal territories with relatively high transcriptional activity on average, closer to the centre of cell's nucleus than those with the lower activity? (ii) Why are actively transcribed genes usually located at the periphery of their chromosomal territories? (iii) Why are pair-wise contacts between active and inactive genes less frequent than those involving only active or only inactive genes? We show that transcription factories-mediated contacts between active genes belonging to different chromosomal territories are instrumental for all these features of nuclear organization to emerge spontaneously due to entropic effects arising when chromatin fibres are highly crowded