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Glioblastoma adaptation traced through decline of an IDH1 clonal driver and macro-evolution of a double-minute chromosome

Favero, F. ; McGranahan, N. ; Salm, M. ; Birkbak, N. J. ; Sanborn, J. Z. ; Benz, S. C. ; Becq, J. ; Peden, J. F. ; Kingsbury, Z. ; Grocok, R. J. ; Humphray, S. ; Bentley, D. ; Spencer-Dene, B. ; Gutteridge, A. ; Brada, M. ; Roger, S. ; Dietrich, P.-Y ; Forshew, T. ; Gerlinger, M. ; Rowan, A. ; Stamp, G. ; Eklund, A. C. ; Szallasi, Z. ; Swanton, C.

In: Annals of Oncology, 2015, vol. 26, no. 5, p. 880-887

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    Titre
    • Glioblastoma adaptation traced through decline of an IDH1 clonal driver and macro-evolution of a double-minute chromosome
    Auteur
    • Favero, F.. Cancer Research UK London Research Institute, London, United Kingdom
    • McGranahan, N.. Cancer Research UK London Research Institute, London, United Kingdom
    • Salm, M.. Cancer Research UK London Research Institute, London, United Kingdom
    • Birkbak, N. J.. Cancer Research UK London Research Institute, London, United Kingdom
    • Sanborn, J. Z.. NantOmics, LLC, Santa Cruz, USA
    • Benz, S. C.. NantOmics, LLC, Santa Cruz, USA
    • Becq, J.. Illumina Ltd, Cambridge
    • Peden, J. F.. Illumina Ltd, Cambridge
    • Kingsbury, Z.. Illumina Ltd, Cambridge
    • Grocok, R. J.. Illumina Ltd, Cambridge
    • Humphray, S.. Illumina Ltd, Cambridge
    • Bentley, D.. Illumina Ltd, Cambridge
    • Spencer-Dene, B.. Cancer Research UK London Research Institute, London, United Kingdom
    • Gutteridge, A.. University College London Cancer Institute, London, United Kingdom
    • Brada, M.. Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool
    • Roger, S.. Department of Oncology, University Hospital Zurich, Zürich
    • Dietrich, P.-Y. Centre of Oncology, University Hospitals of Geneva, Geneva, Switzerland
    • Forshew, T.. University College London Cancer Institute, London, United Kingdom
    • Gerlinger, M.. Cancer Research UK London Research Institute, London, United Kingdom
    • Rowan, A.. Cancer Research UK London Research Institute, London, United Kingdom
    • Stamp, G.. Cancer Research UK London Research Institute, London, United Kingdom
    • Eklund, A. C.. Department of Systems Biology, Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark
    • Szallasi, Z.. Department of Systems Biology, Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark
    • Swanton, C.. Cancer Research UK London Research Institute, London, United Kingdom
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Annals of Oncology, 2015, vol. 26, no. 5, p. 880-887. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:291269
    Summary
    In a glioblastoma tumour with multi-region sequencing before and after recurrence, we find an IDH1 mutation that is clonal in the primary but lost at recurrence. We also describe the evolution of a double-minute chromosome encoding regulators of the PI3K signalling axis that dominates at recurrence, emphasizing the challenges of an evolving and dynamic oncogenic landscape for precision medicine