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Homeostatic Control of Slow-wave and Spindle Frequency Activity during Human Sleep: Effect of Differential Sleep Pressure and Brain Topography

Knoblauch, V. ; Kräuchi, K. ; Renz, C. ; Wirz-Justice, A. ; Cajochen, C.

In: Cerebral Cortex, 2002, vol. 12, no. 10, p. 1092-1100

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    Title
    • Homeostatic Control of Slow-wave and Spindle Frequency Activity during Human Sleep: Effect of Differential Sleep Pressure and Brain Topography
    Author
    • Knoblauch, V.. Center for Chronobiology, Psychiatric University Clinic, CH-4025 Basel, Switzerland
    • Kräuchi, K.. Center for Chronobiology, Psychiatric University Clinic, CH-4025 Basel, Switzerland
    • Renz, C.. Center for Chronobiology, Psychiatric University Clinic, CH-4025 Basel, Switzerland
    • Wirz-Justice, A.. Center for Chronobiology, Psychiatric University Clinic, CH-4025 Basel, Switzerland
    • Cajochen, C.. Center for Chronobiology, Psychiatric University Clinic, CH-4025 Basel, Switzerland
    Document Type
    • Postprint
    Classification
    • Health
    OAI-PMH Identifier
    • oai:doc.rero.ch:290991
    Summary
    The impact of a 40 h sleep deprivation versus a 40 h multiple nap paradigm on topographic and temporal aspects of electroencephalo-graphic (EEG) activity during the subsequent recovery sleep was investigated in 10 young volunteers in a controlled ‘constant posture' protocol. The accumulation of sleep pressure with extended wakefulness could be significantly attenuated by intermittent naps. The differential sleep pressure conditions induced frequency- and topographic-specific changes in the EEG slow wave range (0.5-5 Hz) and in the low (LSFA, 12.25-13.25 Hz) and high spindle frequency activity range (HSFA, 13.75-16.5 Hz) during non-REM sleep. The observed increase of EEG slow-wave activity (SWA) after high sleep pressure was significantly more pronounced in the fronto-central (Fz, Cz) than in the parieto-occipital (Pz, Oz) derivations. Low sleep pressure after the nap paradigm decreased SWA with an occipital predominance. Spindle frequency activity showed a dissimilar homeostatic regulation: HSFA was significantly decreased after high sleep pressure and increased after low sleep pressure, exclusively in the centro-parietal brain region (Cz, Pz). LSFA was significantly enhanced after both manipulations. The data indicate that EEG activity, in particular frontal SWA and centro-parietal HSFA, are under a clear sleep-wake-dependent homeostatic control and imply a reciprocal relationship in the homeostatic regulation of SWA and HSFA, which however shows different spatio-temporal aspects