Fulltext

IL1B and DEFB1 Polymorphisms Increase Susceptibility to Invasive Mold Infection After Solid-Organ Transplantation

Wójtowicz, Agnieszka ; Gresnigt, Mark S. ; Lecompte, Thanh ; Bibert, Stephanie ; Manuel, Oriol ; Joosten, Leo A.B. ; Rüeger, Sina ; Berger, Christoph ; Boggian, Katia ; Cusini, Alexia ; Garzoni, Christian ; Hirsch, Hans H. ; Weisser, Maja ; Mueller, Nicolas J. ; Meylan, Pascal R. ; Steiger, Jürg ; Kutalik, Zoltan ; Pascual, Manuel ; van Delden, Christian ; van de Veerdonk, Frank L. ; Bochud, Pierre-Yves ; Binet, I. ; De Geest, S. ; van Delden, C. ; Hofbauer, G. F. K. ; Huynh-Do, U. ; Koller, M. T. ; Lovis, C. ; Manuel, O. ; Meylan, P. ; Mueller, N. J. ; Pascual, M. ; Schaub, S. ; Steiger, J. ; Binet, I. ; De Geest, S. ; van Delden, C. ; Hofbauer, G. F. K. ; Huynh-Do, U. ; Koller, M. T. ; Lovis, C. ; Manuel, O. ; Meylan, P. ; Mueller, N. J. ; Pascual, M. ; Schaub, S. ; Steiger, J.

In: The Journal of Infectious Diseases, 2015, vol. 211, no. 10, p. 1646-1657

Aggiungi alla tua lista
    Titre
    • IL1B and DEFB1 Polymorphisms Increase Susceptibility to Invasive Mold Infection After Solid-Organ Transplantation
    Auteur
    • Wójtowicz, Agnieszka. Infectious Diseases Service
    • Gresnigt, Mark S.. Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
    • Lecompte, Thanh. Service of Transplantation
    • Bibert, Stephanie. Infectious Diseases Service
    • Manuel, Oriol. Infectious Diseases Service
    • Joosten, Leo A.B.. Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
    • Rüeger, Sina. Institute of Social and Preventive Medicine
    • Berger, Christoph. Division of Infectious Diseases and Hospital Epidemiology, University Children's Hospital Zürich
    • Boggian, Katia. Division of Infectious Diseases and Hospital Epidemiology, Cantonal Hospital St. Gallen
    • Cusini, Alexia. Department of Infectious Diseases, Inselspital, Bern University Hospital and University of Bern
    • Garzoni, Christian. Department of Infectious Diseases, Inselspital, Bern University Hospital and University of Bern
    • Hirsch, Hans H.. Division of Infectious Diseases and Hospital Epidemiology
    • Weisser, Maja. Division of Infectious Diseases and Hospital Epidemiology
    • Mueller, Nicolas J.. Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zürich
    • Meylan, Pascal R.. Infectious Diseases Service
    • Steiger, Jürg. Clinic for Transplantation Immunology and Nephrology, University Hospital of Basel, Switzerland
    • Kutalik, Zoltan. Infectious Diseases Service
    • Pascual, Manuel. Transplantation Center, Department of Surgery
    • van Delden, Christian. Service of Transplantation
    • van de Veerdonk, Frank L.. Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
    • Bochud, Pierre-Yves. Infectious Diseases Service
    • Binet, I.. University Hospital and University of Lausanne, Infectious Diseases Service, Transplantation Center, Department of Surgery, Institute of Social and Preventive Medicine, Institute of Microbiology, Lausanne, Service of Transplantation, Service of Infectious Diseases, Division of Infectious Diseases and Hospital Epidemiology, Division of Infectious Diseases and Hospital Epidemiology, Division of Infectious Diseases and Hospital Epidemiology, Department of Infectious Diseases, Department of Internal Medicine, Department of Infectious Disease, Lugano, Division of Infectious Diseases and Hospital Epidemiology, Clinic for Transplantation Immunology and Nephrology, Department of Internal Medicine, Nijmegen, Switzerland, The Netherlands
    • De Geest, S.. University Hospital and University of Lausanne, Infectious Diseases Service, Transplantation Center, Department of Surgery, Institute of Social and Preventive Medicine, Institute of Microbiology, Lausanne, Service of Transplantation, Service of Infectious Diseases, Division of Infectious Diseases and Hospital Epidemiology, Division of Infectious Diseases and Hospital Epidemiology, Division of Infectious Diseases and Hospital Epidemiology, Department of Infectious Diseases, Department of Internal Medicine, Department of Infectious Disease, Lugano, Division of Infectious Diseases and Hospital Epidemiology, Clinic for Transplantation Immunology and Nephrology, Department of Internal Medicine, Nijmegen, Switzerland, The Netherlands
    • van Delden, C.. University Hospital and University of Lausanne, Infectious Diseases Service, Transplantation Center, Department of Surgery, Institute of Social and Preventive Medicine, Institute of Microbiology, Lausanne, Service of Transplantation, Service of Infectious Diseases, Division of Infectious Diseases and Hospital Epidemiology, Division of Infectious Diseases and Hospital Epidemiology, Division of Infectious Diseases and Hospital Epidemiology, Department of Infectious Diseases, Department of Internal Medicine, Department of Infectious Disease, Lugano, Division of Infectious Diseases and Hospital Epidemiology, Clinic for Transplantation Immunology and Nephrology, Department of Internal Medicine, Nijmegen, Switzerland, The Netherlands
    • Hofbauer, G. F. K.. University Hospital and University of Lausanne, Infectious Diseases Service, Transplantation Center, Department of Surgery, Institute of Social and Preventive Medicine, Institute of Microbiology, Lausanne, Service of Transplantation, Service of Infectious Diseases, Division of Infectious Diseases and Hospital Epidemiology, Division of Infectious Diseases and Hospital Epidemiology, Division of Infectious Diseases and Hospital Epidemiology, Department of Infectious Diseases, Department of Internal Medicine, Department of Infectious Disease, Lugano, Division of Infectious Diseases and Hospital Epidemiology, Clinic for Transplantation Immunology and Nephrology, Department of Internal Medicine, Nijmegen, Switzerland, The Netherlands
    • Huynh-Do, U.. University Hospital and University of Lausanne, Infectious Diseases Service, Transplantation Center, Department of Surgery, Institute of Social and Preventive Medicine, Institute of Microbiology, Lausanne, Service of Transplantation, Service of Infectious Diseases, Division of Infectious Diseases and Hospital Epidemiology, Division of Infectious Diseases and Hospital Epidemiology, Division of Infectious Diseases and Hospital Epidemiology, Department of Infectious Diseases, Department of Internal Medicine, Department of Infectious Disease, Lugano, Division of Infectious Diseases and Hospital Epidemiology, Clinic for Transplantation Immunology and Nephrology, Department of Internal Medicine, Nijmegen, Switzerland, The Netherlands
    • Koller, M. T.. University Hospital and University of Lausanne, Infectious Diseases Service, Transplantation Center, Department of Surgery, Institute of Social and Preventive Medicine, Institute of Microbiology, Lausanne, Service of Transplantation, Service of Infectious Diseases, Division of Infectious Diseases and Hospital Epidemiology, Division of Infectious Diseases and Hospital Epidemiology, Division of Infectious Diseases and Hospital Epidemiology, Department of Infectious Diseases, Department of Internal Medicine, Department of Infectious Disease, Lugano, Division of Infectious Diseases and Hospital Epidemiology, Clinic for Transplantation Immunology and Nephrology, Department of Internal Medicine, Nijmegen, Switzerland, The Netherlands
    • Lovis, C.. University Hospital and University of Lausanne, Infectious Diseases Service, Transplantation Center, Department of Surgery, Institute of Social and Preventive Medicine, Institute of Microbiology, Lausanne, Service of Transplantation, Service of Infectious Diseases, Division of Infectious Diseases and Hospital Epidemiology, Division of Infectious Diseases and Hospital Epidemiology, Division of Infectious Diseases and Hospital Epidemiology, Department of Infectious Diseases, Department of Internal Medicine, Department of Infectious Disease, Lugano, Division of Infectious Diseases and Hospital Epidemiology, Clinic for Transplantation Immunology and Nephrology, Department of Internal Medicine, Nijmegen, Switzerland, The Netherlands
    • Manuel, O.. University Hospital and University of Lausanne, Infectious Diseases Service, Transplantation Center, Department of Surgery, Institute of Social and Preventive Medicine, Institute of Microbiology, Lausanne, Service of Transplantation, Service of Infectious Diseases, Division of Infectious Diseases and Hospital Epidemiology, Division of Infectious Diseases and Hospital Epidemiology, Division of Infectious Diseases and Hospital Epidemiology, Department of Infectious Diseases, Department of Internal Medicine, Department of Infectious Disease, Lugano, Division of Infectious Diseases and Hospital Epidemiology, Clinic for Transplantation Immunology and Nephrology, Department of Internal Medicine, Nijmegen, Switzerland, The Netherlands
    • Meylan, P.. University Hospital and University of Lausanne, Infectious Diseases Service, Transplantation Center, Department of Surgery, Institute of Social and Preventive Medicine, Institute of Microbiology, Lausanne, Service of Transplantation, Service of Infectious Diseases, Division of Infectious Diseases and Hospital Epidemiology, Division of Infectious Diseases and Hospital Epidemiology, Division of Infectious Diseases and Hospital Epidemiology, Department of Infectious Diseases, Department of Internal Medicine, Department of Infectious Disease, Lugano, Division of Infectious Diseases and Hospital Epidemiology, Clinic for Transplantation Immunology and Nephrology, Department of Internal Medicine, Nijmegen, Switzerland, The Netherlands
    • Mueller, N. J.. University Hospital and University of Lausanne, Infectious Diseases Service, Transplantation Center, Department of Surgery, Institute of Social and Preventive Medicine, Institute of Microbiology, Lausanne, Service of Transplantation, Service of Infectious Diseases, Division of Infectious Diseases and Hospital Epidemiology, Division of Infectious Diseases and Hospital Epidemiology, Division of Infectious Diseases and Hospital Epidemiology, Department of Infectious Diseases, Department of Internal Medicine, Department of Infectious Disease, Lugano, Division of Infectious Diseases and Hospital Epidemiology, Clinic for Transplantation Immunology and Nephrology, Department of Internal Medicine, Nijmegen, Switzerland, The Netherlands
    • Pascual, M.. University Hospital and University of Lausanne, Infectious Diseases Service, Transplantation Center, Department of Surgery, Institute of Social and Preventive Medicine, Institute of Microbiology, Lausanne, Service of Transplantation, Service of Infectious Diseases, Division of Infectious Diseases and Hospital Epidemiology, Division of Infectious Diseases and Hospital Epidemiology, Division of Infectious Diseases and Hospital Epidemiology, Department of Infectious Diseases, Department of Internal Medicine, Department of Infectious Disease, Lugano, Division of Infectious Diseases and Hospital Epidemiology, Clinic for Transplantation Immunology and Nephrology, Department of Internal Medicine, Nijmegen, Switzerland, The Netherlands
    • Schaub, S.. University Hospital and University of Lausanne, Infectious Diseases Service, Transplantation Center, Department of Surgery, Institute of Social and Preventive Medicine, Institute of Microbiology, Lausanne, Service of Transplantation, Service of Infectious Diseases, Division of Infectious Diseases and Hospital Epidemiology, Division of Infectious Diseases and Hospital Epidemiology, Division of Infectious Diseases and Hospital Epidemiology, Department of Infectious Diseases, Department of Internal Medicine, Department of Infectious Disease, Lugano, Division of Infectious Diseases and Hospital Epidemiology, Clinic for Transplantation Immunology and Nephrology, Department of Internal Medicine, Nijmegen, Switzerland, The Netherlands
    • Steiger, J.. University Hospital and University of Lausanne, Infectious Diseases Service, Transplantation Center, Department of Surgery, Institute of Social and Preventive Medicine, Institute of Microbiology, Lausanne, Service of Transplantation, Service of Infectious Diseases, Division of Infectious Diseases and Hospital Epidemiology, Division of Infectious Diseases and Hospital Epidemiology, Division of Infectious Diseases and Hospital Epidemiology, Department of Infectious Diseases, Department of Internal Medicine, Department of Infectious Disease, Lugano, Division of Infectious Diseases and Hospital Epidemiology, Clinic for Transplantation Immunology and Nephrology, Department of Internal Medicine, Nijmegen, Switzerland, The Netherlands
    • Binet, I.. Correspondence: Pierre-Yves Bochud, MD, Infectious Diseases Service, Department of Medicine, Lausanne University Hospital, Rue du Bugnon 46, CH-1011 Lausanne, Switzerland (
    • De Geest, S.. Correspondence: Pierre-Yves Bochud, MD, Infectious Diseases Service, Department of Medicine, Lausanne University Hospital, Rue du Bugnon 46, CH-1011 Lausanne, Switzerland (
    • van Delden, C.. Correspondence: Pierre-Yves Bochud, MD, Infectious Diseases Service, Department of Medicine, Lausanne University Hospital, Rue du Bugnon 46, CH-1011 Lausanne, Switzerland (
    • Hofbauer, G. F. K.. Correspondence: Pierre-Yves Bochud, MD, Infectious Diseases Service, Department of Medicine, Lausanne University Hospital, Rue du Bugnon 46, CH-1011 Lausanne, Switzerland (
    • Huynh-Do, U.. Correspondence: Pierre-Yves Bochud, MD, Infectious Diseases Service, Department of Medicine, Lausanne University Hospital, Rue du Bugnon 46, CH-1011 Lausanne, Switzerland (
    • Koller, M. T.. Correspondence: Pierre-Yves Bochud, MD, Infectious Diseases Service, Department of Medicine, Lausanne University Hospital, Rue du Bugnon 46, CH-1011 Lausanne, Switzerland (
    • Lovis, C.. Correspondence: Pierre-Yves Bochud, MD, Infectious Diseases Service, Department of Medicine, Lausanne University Hospital, Rue du Bugnon 46, CH-1011 Lausanne, Switzerland (
    • Manuel, O.. Correspondence: Pierre-Yves Bochud, MD, Infectious Diseases Service, Department of Medicine, Lausanne University Hospital, Rue du Bugnon 46, CH-1011 Lausanne, Switzerland (
    • Meylan, P.. Correspondence: Pierre-Yves Bochud, MD, Infectious Diseases Service, Department of Medicine, Lausanne University Hospital, Rue du Bugnon 46, CH-1011 Lausanne, Switzerland (
    • Mueller, N. J.. Correspondence: Pierre-Yves Bochud, MD, Infectious Diseases Service, Department of Medicine, Lausanne University Hospital, Rue du Bugnon 46, CH-1011 Lausanne, Switzerland (
    • Pascual, M.. Correspondence: Pierre-Yves Bochud, MD, Infectious Diseases Service, Department of Medicine, Lausanne University Hospital, Rue du Bugnon 46, CH-1011 Lausanne, Switzerland (
    • Schaub, S.. Correspondence: Pierre-Yves Bochud, MD, Infectious Diseases Service, Department of Medicine, Lausanne University Hospital, Rue du Bugnon 46, CH-1011 Lausanne, Switzerland (
    • Steiger, J.. Correspondence: Pierre-Yves Bochud, MD, Infectious Diseases Service, Department of Medicine, Lausanne University Hospital, Rue du Bugnon 46, CH-1011 Lausanne, Switzerland (
    Type de document
    • Postprint
    Langue
    • Inglese
    Publié dans
    • The Journal of Infectious Diseases, 2015, vol. 211, no. 10, p. 1646-1657. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:290628
    Summary
    Background. Single-nucleotide polymorphisms (SNPs) in immune genes have been associated with susceptibility to invasive mold infection (IMI) among hematopoietic stem cell but not solid-organ transplant (SOT) recipients. Methods. Twenty-four SNPs from systematically selected genes were genotyped among 1101 SOT recipients (715 kidney transplant recipients, 190 liver transplant recipients, 102 lung transplant recipients, 79 heart transplant recipients, and 15 recipients of other transplants) from the Swiss Transplant Cohort Study. Association between SNPs and the end point were assessed by log-rank test and Cox regression models. Cytokine production upon Aspergillus stimulation was measured by enzyme-linked immunosorbent assay in peripheral blood mononuclear cells (PBMCs) from healthy volunteers and correlated with relevant genotypes. Results. Mold colonization (n = 45) and proven/probable IMI (n = 26) were associated with polymorphisms in the genes encoding interleukin 1β (IL1B; rs16944; recessive mode, P = .001 for colonization and P = .00005 for IMI, by the log-rank test), interleukin 1 receptor antagonist (IL1RN; rs419598; P = .01 and P = .02, respectively), and β-defensin 1 (DEFB1; rs1800972; P = .001 and P = .0002, respectively). The associations with IL1B and DEFB1 remained significant in a multivariate regression model (P = .002 for IL1B rs16944; P = .01 for DEFB1 rs1800972). The presence of 2 copies of the rare allele of rs16944 or rs419598 was associated with reduced Aspergillus-induced interleukin 1β and tumor necrosis factor α secretion by PBMCs. Conclusions. Functional polymorphisms in IL1B and DEFB1 influence susceptibility to mold infection in SOT recipients. This observation may contribute to individual risk stratification