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Contribution of Tumor Necrosis Factor to Host Defense against Staphylococci in a Guinea Pig Model of Foreign Body Infections

Vaudaux, Pierre ; Grau, Georges E. ; Huggler, Elzbieta ; Schumacher-Perdreau, Françoise ; Fiedle, Franz ; Waldvogel, Francis A. ; Lew, Daniel P.

In: Journal of Infectious Diseases, 1992, vol. 166, no. 1, p. 58-64

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    Titre
    • Contribution of Tumor Necrosis Factor to Host Defense against Staphylococci in a Guinea Pig Model of Foreign Body Infections
    Auteur
    • Vaudaux, Pierre. Division of Infectious Diseases, Department of Medicine, University Hospital, and Department of Pathology, University of Geneva, Switzerland, Germany
    • Grau, Georges E.. Division of Infectious Diseases, Department of Medicine, University Hospital, and Department of Pathology, University of Geneva, Switzerland, Germany
    • Huggler, Elzbieta. Division of Infectious Diseases, Department of Medicine, University Hospital, and Department of Pathology, University of Geneva, Switzerland, Germany
    • Schumacher-Perdreau, Françoise. Division of Infectious Diseases, Department of Medicine, University Hospital, and Department of Pathology, University of Geneva, Switzerland, Germany
    • Fiedle, Franz. Division of Infectious Diseases, Department of Medicine, University Hospital, and Department of Pathology, University of Geneva, Switzerland, Germany
    • Waldvogel, Francis A.. Division of Infectious Diseases, Department of Medicine, University Hospital, and Department of Pathology, University of Geneva, Switzerland, Germany
    • Lew, Daniel P.. Division of Infectious Diseases, Department of Medicine, University Hospital, and Department of Pathology, University of Geneva, Switzerland, Germany
    Type de document
    • Postprint
    Langue
    • Inglese
    Publié dans
    • Journal of Infectious Diseases, 1992, vol. 166, no. 1, p. 58-64. The University of Chicago Press
    Autre version électronique
    Classification
    • Santé
    Identifiant OAI-PMH
    • oai:doc.rero.ch:290114
    Summary
    The contribution of the cytokine tumor necrosis factor (cachectin; TNF) to host defenses against staphylococcal foreign body infections was studied in vivo. In tissue cages subcutaneously implanted into guinea pigs, progressive infection was initiated by a very low inoculum (100 cfu) of Staphylococcus aureus with a success rate of 100%, as is frequently encountered in related clinical situations. Locally injected autologous bacterial components derived from the cell wall of S. aureus, in particular peptidoglycan, were very active in raising TNF levels in tissue cage fluid and in preventing the development of infection by the 100% infective dose of the test strain. Furthermore, injection of murine recombinant TNF into tissue cages could substitute for the bacterial components in preventing experimental infection by S. aureus. The protective effect of TNF-eliciting bacterial components could be neutralized by anti-TNF antibodies. A local increase in TNF levels might improve host defenses against staphylococcal foreign body infections