First-line treatment and outcome of elderly patients with primary central nervous system lymphoma (PCNSL)—a systematic review and individual patient data meta-analysis
Kasenda, B. ; Ferreri, A. J. M. ; Marturano, E. ; Forst, D. ; Bromberg, J. ; Ghesquieres, H. ; Ferlay, C. ; Blay, J. Y. ; Hoang-Xuan, K. ; Pulczynski, E. J. ; Fosså, A. ; Okoshi, Y. ; Chiba, S. ; Fritsch, K. ; Omuro, A. ; O'Neill, B. P. ; Bairey, O. ; Schandelmaier, S. ; Gloy, V. ; Bhatnagar, N. ; Haug, S. ; Rahner, S. ; Batchelor, T. T. ; Illerhaus, G. ; Briel, M.
In: Annals of Oncology, 2015, vol. 26, no. 7, p. 1305-1313
Zum persönliche Liste hinzufügen- Summary
- Evidence for prognosis and treatment of elderly patient with primary central nervous system is limited. High-dose methotrexate should be applied whenever possible, especially combination with oral alkylating agents is a promising approach. Further combinations with other intravenous drugs do not seem to improve outcome. More prospective trials designed for elderly PCNSL patients are warranted