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Hepatitis B Virus Infection Is Associated With Impaired Immunological Recovery During Antiretroviral Therapy in the Swiss HIV Cohort Study

Wandeler, Gilles ; Gsponer, Thomas ; Bihl, Florian ; Bernasconi, Enos ; Cavassini, Matthias ; Kovari, Helen ; Schmid, Patrick ; Battegay, Manuel ; Calmy, Alexandra ; Egger, Matthias ; Furrer, Hansjakob ; Rauch, Andri ; Aubert, V. ; Barth, J. ; Battegay, M. ; Bernasconi, E. ; Böni, J. ; Bucher, H.C. ; Burton-Jeangros, C. ; Calmy, A. ; Cavassini, M. ; Egger, M. ; Elzi, L. ; Fehr, J. ; Fellay, J. ; Francioli, P. ; Furrer, H. ; Fux, C.A. ; Gorgievski, M. ; Günthard, H. ; Haerry, D. ; Hasse, B. ; Hirsch, H.H. ; Hirschel, B. ; Hösli, I. ; Kahlert, C. ; Kaiser, L. ; Keiser, O. ; Kind, C. ; Klimkait, T. ; Kovari, H. ; Ledergerber, B. ; Martinetti, G. ; Martinez de Tejada, B. ; Metzner, K. ; Müller, N. ; Nadal, D. ; Pantaleo, G. ; Rauch, A. ; Regenass, S. ; Rickenbach, M. ; Rudin, C. ; Schmid, P. ; Schultze, D. ; Schöni-Affolter, F. ; Schüpbach, J. ; Speck, R. ; Taffé, P. ; Tarr, P. ; Telenti, A. ; Trkola, A. ; Vernazza, P. ; Weber, R. ; Yerly, S.

In: The Journal of Infectious Diseases, 2013, vol. 208, no. 9, p. 1454-1458

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    Title
    • Hepatitis B Virus Infection Is Associated With Impaired Immunological Recovery During Antiretroviral Therapy in the Swiss HIV Cohort Study
    Author
    • Wandeler, Gilles. Department of Infectious Diseases, Bern University Hospital and University of Bern
    • Gsponer, Thomas. Institute of Social and Preventive Medicine, University of Bern
    • Bihl, Florian. Regional Hospital, Lugano
    • Bernasconi, Enos. Regional Hospital, Lugano
    • Cavassini, Matthias. University Hospital Lausanne
    • Kovari, Helen. Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich
    • Schmid, Patrick. Cantonal Hospital, St. Gallen
    • Battegay, Manuel. University Hospital Basel
    • Calmy, Alexandra. University Hospital Geneva, Switzerland
    • Egger, Matthias. Institute of Social and Preventive Medicine, University of Bern
    • Furrer, Hansjakob. Department of Infectious Diseases, Bern University Hospital and University of Bern
    • Rauch, Andri. Department of Infectious Diseases, Bern University Hospital and University of Bern
    • Aubert, V.
    • Barth, J.
    • Battegay, M.
    • Bernasconi, E.
    • Böni, J.
    • Bucher, H.C.
    • Burton-Jeangros, C.
    • Calmy, A.
    • Cavassini, M.
    • Egger, M.
    • Elzi, L.
    • Fehr, J.
    • Fellay, J.
    • Francioli, P.
    • Furrer, H.
    • Fux, C.A.
    • Gorgievski, M.
    • Günthard, H.
    • Haerry, D.
    • Hasse, B.
    • Hirsch, H.H.
    • Hirschel, B.
    • Hösli, I.
    • Kahlert, C.
    • Kaiser, L.
    • Keiser, O.
    • Kind, C.
    • Klimkait, T.
    • Kovari, H.
    • Ledergerber, B.
    • Martinetti, G.
    • Martinez de Tejada, B.
    • Metzner, K.
    • Müller, N.
    • Nadal, D.
    • Pantaleo, G.
    • Rauch, A.
    • Regenass, S.
    • Rickenbach, M.
    • Rudin, C.
    • Schmid, P.
    • Schultze, D.
    • Schöni-Affolter, F.
    • Schüpbach, J.
    • Speck, R.
    • Taffé, P.
    • Tarr, P.
    • Telenti, A.
    • Trkola, A.
    • Vernazza, P.
    • Weber, R.
    • Yerly, S.
    Document Type
    • Postprint
    Language
    • English
    Published in
    • The Journal of Infectious Diseases, 2013, vol. 208, no. 9, p. 1454-1458. Oxford University Press
    Other Version
    OAI-PMH Identifier
    • oai:doc.rero.ch:289915
    Summary
    Hepatitis B virus (HBV) infection is a major cause of morbidity and mortality in human immunodeficiency virus (HIV)-infected patients worldwide. It is unclear whether HIV-related outcomes are affected by HBV coinfection. We compared virological suppression and immunological recovery during antiretroviral therapy (ART) of patients of different HBV serological status in the Swiss HIV Cohort Study. CD4 cell recovery during ART was significantly impaired in hepatitis B surface antigen-positive patients and in those with anti-hepatitis B core antigen alone compared with HBV-uninfected patients, despite similar virological efficacy of ART. CD4 increase in patients with resolved HBV infection was similar to that in HBV-uninfected individuals