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Prevalence and Predictors for Homo- and Heterosubtypic Antibodies Against Influenza A Virus

Kohler, Ines ; Scherrer, Alexandra U. ; Zagordi, Osvaldo ; Bianchi, Matteo ; Wyrzucki, Arkadiusz ; Steck, Marco ; Ledergerber, Bruno ; Günthard, Huldrych F. ; Hangartner, Lars

In: Clinical Infectious Diseases, 2014, vol. 59, no. 10, p. 1386-1393

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    Title
    • Prevalence and Predictors for Homo- and Heterosubtypic Antibodies Against Influenza A Virus
    Author
    • Kohler, Ines. Institute of Medical Virology, University of Zurich
    • Scherrer, Alexandra U.. Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Switzerland
    • Zagordi, Osvaldo. Institute of Medical Virology, University of Zurich
    • Bianchi, Matteo. Institute of Medical Virology, University of Zurich
    • Wyrzucki, Arkadiusz. Institute of Medical Virology, University of Zurich
    • Steck, Marco. Institute of Medical Virology, University of Zurich
    • Ledergerber, Bruno. Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Switzerland
    • Günthard, Huldrych F.. Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Switzerland
    • Hangartner, Lars. Institute of Medical Virology, University of Zurich
    Document Type
    • Postprint
    Language
    • English
    Published in
    • Clinical Infectious Diseases, 2014, vol. 59, no. 10, p. 1386-1393. Oxford University Press
    Other Version
    OAI-PMH Identifier
    • oai:doc.rero.ch:289566
    Summary
    Heterosubtypic antibodies to influenza A virus will be crucial for the development of a pan-influenza vaccine. Here we show that most individuals already possess heterosubtypic antibodies and that their generation is favored both by vaccination and age