Université de Fribourg

Pathways from dieting to weight regain, to obesity and to the metabolic syndrome: an overview

Dulloo, Abdull G. ; Montani, Jean-Pierre

In: Obesity Reviews, 2015, vol. 16, p. 1–6

Every year, scores of millions of people – as diverse as obese and lean, teenagers and older adults, sedentary and elite athletes, commoners and celebrities – attempt to lose weight on some form of diet. They are often encouraged by their parents, friends, health professionals, training coaches, a media that promotes a slim image and a diet-industry that in Europe and United States alone has...

Université de Fribourg

Adaptive thermogenesis in human body weight regulation: more of a concept than a measurable entity?

Dulloo, Abdul G. ; Jacquet, Jean ; Montani, Jean-Pierre ; Schutz, Yves

In: Obesity Reviews, 2012, vol. 13, no. S2, p. 105–121

According to Lavoisier, ‘Life is combustion’. But to what extent humans adapt to changes in food intake through adaptive thermogenesis – by turning down the rate of heat production during energy deficit (so as to conserve energy) or turning it up during overnutrition (so as to dissipate excess calories) – has been one of the most controversial issues in nutritional sciences over the past...

Université de Fribourg

Adaptive thermogenesis and uncoupling proteins: a reappraisal of their roles in fat metabolism and energy balance

Dulloo, Abdul G. ; Seydoux, Josiane ; Jacquet, Jean

In: Physiology & Behavior, 2004, vol. 83(4), p. 587-602

After decades of controversies about the quantitative importance of autoregulatory adjustments in energy expenditure in weight regulation, there is now increasing recognition that even subtle variations in thermogenesis could, in dynamic systems and over the long term, be important in determining weight maintenance in some and obesity in others. The main challenge nowadays is to provide a...