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Université de Fribourg

Reduced caterpillar damage can benefit plant bugs in Bt cotton

Eisenring, Michael ; Naranjo, Steven E. ; Bacher, Sven ; Abbott, Angelique ; Meissle, Michael ; Romeis, Jörg

In: Scientific Reports, 2019, vol. 9, no. 1, p. 2727

Bt cotton was genetically modified to produce insecticidal proteins targeting Lepidopteran pests and is therefore only minimally affected by caterpillar damage. This could lead to reduced levels of inherent, systemically inducible defensive compounds in Bt cotton which might benefit other important cotton herbivores such as plant bugs. We studied the effects of plant defense induction on the...

Università della Svizzera italiana

Dnmt3a restrains mast cell inflammatory responses

Leoni, Cristina ; Montagner, Sara ; Rinaldi, Andrea ; Bertoni, Francesco ; Polletti, Sara ; Balestrieri, Chiara ; Monticelli, Silvia

In: Proceedings of the national academy of sciences, 2017, vol. 114, no. 8, p. E1490-E1499

DNA methylation and specifically the DNA methyltransferase enzyme DNMT3A are involved in the pathogenesis of a variety of hematological diseases and in regulating the function of immune cells. Although altered DNA methylation patterns and mutations in DNMT3A correlate with mast cell proliferative disorders in humans, the role of DNA methylation in mast cell biology is not understood. By using...

Università della Svizzera italiana

ACKR3 expression on diffuse large B cell lymphoma is required for tumor spreading and tissue infiltration

Puddinu, Viola ; Casella, Sabrina ; Radice, Egle ; Thelen, Sylvia ; Dirnhofer, Stefan ; Bertoni, Francesco ; Thelen, Marcus

In: Oncotarget, 2017, vol. 8, no. 49, p. 85068-85084

Diffuse large B cell lymphoma (DLBCL) is the most frequent lymphoma accounting for more than the 30% of the cases. Involvement of extranodal sites, such as bone marrow and central nervous system, is associated with poor prognosis. A contribution of the chemokine system in these processes is assumed as it is known as a critical regulator of the metastatic process in cancer. The atypical...

Università della Svizzera italiana

Chemical stresses fail to mimic the unfolded protein response resulting from luminal load with unfolded polypeptides

Bergmann, Timothy J. ; Fregno, Ilaria ; Fumagalli, Fiorenza ; Rinaldi, Andrea ; Bertoni, Francesco ; Boersema, Paul J. ; Picotti, Paola ; Molinari, Maurizio

In: Journal of biological chemistry, 2018, vol. 293, no. 15, p. 5600-5612

The stress sensors ATF6, IRE1, and PERK monitor deviations from homeostatic conditions in the endoplasmic reticulum (ER), a protein biogenesis compartment of eukaryotic cells. Their activation elicits unfolded protein responses (UPR) to reestablish proteostasis. UPR have been extensively investigated in cells exposed to chemicals that activate ER stress sensors by perturbing calcium, N-glycans,...

Università della Svizzera italiana

P2X7 receptor restrains pathogenic Tfh cell generation in systemic lupus erythematosus

Faliti, Caterina E. ; Gualtierotti, Roberta ; Rottoli, Elsa ; Gerosa, Maria ; Perruzza, Lisa ; Romagnani, Andrea ; Pellegrini, Giovanni ; De Ponte Conti, Benedetta ; Rossi, Riccardo L. ; Idzko, Marco ; Mazza, Emilia M.C. ; Bicciato, Silvio ; Traggiai, Elisabetta ; Meroni, Pier Luigi ; Grassi, Fabio

In: Journal of Experimental Medicine, 2019, vol. 216, no. 2, p. 317-336

Altered control of T follicular helper (Tfh) cells can lead to generation of autoantibodies and autoimmune manifestations. Signaling pathways that selectively limit pathogenic responses without affecting the protective function of Tfh cells are unknown. Here we show that the ATP-gated ionotropic P2X7 receptor restricts the expansion of aberrant Tfh cells and the generation of self-reactive...

Université de Neuchâtel

Respiratory physiology and anthropophilic behavioural traits of the main malaria vector "Anopheles gambiae" Giles (Diptera: Culicidae)

Frei, Jérôme ; Guerin, Patrick (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2018.

La vie adulte des moustiques est marquée par la répétition de séquences comportementales incluant: la recherche d’un partenaire sexuel, la recherche de ressources (repas sanguin sur un hôte ou sucre d’origine végétale) et la recherche d’un site de ponte ; ces séquences comportementales étant intercalées de périodes plus ou moins longues de repos. L’entreprise de l’un ou...

Université de Neuchâtel

Oxidative stress as a life history constraint : pespectives from a bat species with alternative reproductive tactics

Meniri, Magali ; Helfenstein, Fabrice (Dir.) ; Fasel, Nicolas (Codir.)

Thèse de doctorat : Université de Neuchâtel, 2018.

Au cours de cette thèse, j’ai étudié le rôle du stress oxydant en tant que contrainte pour les traits d’histoire de vie, en utilisant les chauves-souris Fer de lance à lunettes (Carollia perspicillata) comme modèle d’étude. Chez cette espèce, les mâles présentent trois tactiques de reproduction alternatives qui ont des succès reproducteurs différents, et dont...

Université de Fribourg

HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα

Rita, Anthea Di ; Peschiaroli, Angelo ; D?Acunzo, Pasquale ; Strobbe, Daniela ; Hu, Zehan ; Gruber, Jens ; Nygaard, Mads ; Lambrughi, Matteo ; Melino, Gerry ; Papaleo, Elena ; Dengjel, Jörn ; Alaoui, Said El ; Campanella, Michelangelo ; Dötsch, Volker ; Rogov, Vladimir V. ; Strappazzon, Flavie ; Cecconi, Francesco

In: Nature Communications, 2018, vol. 9, no. 1, p. 3755

The selective removal of undesired or damaged mitochondria by autophagy, known as mitophagy, is crucial for cellular homoeostasis, and prevents tumour diffusion, neurodegeneration and ageing. The pro-autophagic molecule AMBRA1 (autophagy/beclin-1 regulator-1) has been defined as a novel regulator of mitophagy in both PINK1/PARKIN-dependent and -independent systems. Here, we identified the E3...

Université de Fribourg

A conserved RxLR effector interacts with host RABA-type GTPases to inhibit vesicle-mediated secretion of antimicrobial proteins

Tomczynska, Iga ; Stumpe, Michael ; Mauch, Felix

In: The Plant Journal, 2018, vol. 95, no. 2, p. 187–203

Plant pathogens of the oomycete genus Phytophthora produce virulence factors, known as RxLR effector proteins that are transferred into host cells to suppress disease resistance. Here, we analyse the function of the highly conserved RxLR24 effector of Phytophthora brassicae. RxLR24 was expressed early in the interaction with Arabidopsis plants and ectopic expression in the host enhanced leaf...