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Uncoupling protein-3 as a molecular determinant of the action of 3,5,3′-triiodothyronine on energy metabolism

Flandin, Pierre ; Lehr, Lorenz ; Asensio, Cedric ; Giacobino, Jean-Paul ; Rohner-Jeanrenaud, Françoise ; Muzzin, Patrick ; Jimenez, Maria

In: Endocrine, 2009, vol. 36, no. 2, p. 246-254

Divergent effects of oxytocin treatment of obese diabetic mice on adiposity and diabetes

Altirriba, Jordi ; Poher, Anne-Laure ; Caillon, Aurélie ; Arsenijevic, Denis ; Veyrat-Durebex, Christelle ; Lyautey, Jacqueline ; Dulloo, Abdul G. ; Rohner-Jeanrenaud, Françoise

In: Endocrinology, 2014, vol. 155, no. 11, p. 4189–4201

Oxytocin has been suggested as a novel therapeutic against obesity, because it induces weight loss and improves glucose tolerance in diet-induced obese rodents. A recent clinical pilot study confirmed the oxytocin-induced weight-reducing effect in obese nondiabetic subjects. Nevertheless, the mechanisms involved and the impact on the main comorbidity associated with obesity, type 2 diabetes,...

A role for adipose tissue de novo lipogenesis in glucose homeostasis during catch-up growth : a randle cycle favoring fat storage

Marcelino, Helena ; Veyrat-Durebex, Christelle ; Summermatter, Serge ; Sarafian, Delphine ; Miles-Chan, Jennifer L. ; Arsenijevic, Denis ; Zani, Fabio ; Montani, Jean-Pierre ; Seydoux, Josiane ; Solinas, Giovanni ; Rohner-Jeanrenaud, Françoise ; Dulloo, Abdul G.

In: Diabetes, 2013, vol. 62, no. 2, p. 362-372

Catch-up growth, a risk factor for type 2 diabetes, is characterized by hyperinsulinemia and accelerated body fat recovery. Using a rat model of semistarvation-refeeding that exhibits catch-up fat, we previously reported that during refeeding on a low-fat diet, glucose tolerance is normal but insulin-dependent glucose utilization is decreased in skeletal muscle and increased in adipose...