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The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors

Schmutz, Isabelle ; Ripperger, Jürgen A. ; Baeriswyl-Aebischer, Stéphanie ; Albrecht, Urs

In: Genes & Development, 2010, vol. 24, p. 345-357

Mammalian circadian clocks provide a temporal framework to synchronize biological functions. To obtain robust rhythms with a periodicity of about a day, these clocks use molecular oscillators consisting of two interlocked feedback loops. The core loop generates rhythms by transcriptional repression via the Period (PER) and Cryptochrome (CRY) proteins, whereas the stabilizing loop establishes...