In: Gut microbes, 2021, vol. 13, no. 1, p. 20
Intestinal microbiota regulates multiple host metabolic and immunological processes. Consequently, any difference in its qualitative and quantitative composition is susceptible to exert significant effects, in particular along the gut-liver axis. Indeed, recent findings suggest that such changes modulate the severity and the evolution of a wide spectrum of hepatobiliary disorders. However, the...
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In: Toxicological Sciences, 2017, vol. 159, no. 1, p. 266-276
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In: European Journal of Pediatrics, 2015, vol. 174, no. 2, p. 151-167
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In: Diabetologia, 2015, vol. 58, no. 2, p. 221-232
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In: Advances in Nutrition, 2017, vol. 8, no. 6, p. 839-849
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In: Diabetologia, 2015, vol. 58, no. 3, p. 558-565
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In: Current Biology, 2020, vol. 30, no. 19, p. 3775-3787.e7
Sphingolipids play important roles in physiology and cell biology, but a systematic examination of their functions is lacking. We performed a genome-wide CRISPRi screen in sphingolipid-depleted human cells and identified hypersensitive mutants in genes of membrane trafficking and lipid biosynthesis, including ether lipid synthesis. Systematic lipidomic analysis showed a coordinate regulation...
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In: Cells, 2020, vol. 9, no. 7, p. 1695
The aged population is currently at its highest level in human history and is expected to increase further in the coming years. In humans, aging is accompanied by impaired angiogenesis, diminished blood flow and altered metabolism, among others. A cellular mechanism that impinges upon these manifestations of aging can be a suitable target for therapeutic intervention. Here we identify cell...
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In: Journal of Infection, 2020, vol. 81, no. 1, p. 17–47
Breastfeeding is associated with considerable health benefits for infants. Aside from essential nutrients, immune cells and bioactive components, breast milk also contains a diverse range of microbes, which are important for maintaining mammary and infant health. In this review, we summarise studies that have investigated the composition of the breast milk microbiota and factors that might...
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In: Nature communications, 2017, vol. 8, p. 1917
The melastatin-like transient-receptor-potential-7 protein (TRPM7), harbouring a cation channel and a serine/threonine kinase, has been implicated in thymopoiesis and cytokine expression. Here we show, by analysing TRPM7 kinase-dead mutant (Trpm7 R/R) mice, that the enzymatic activity of the receptor is not essential for thymopoiesis, but is required for CD103 transcription and gut-homing of ...
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