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Università della Svizzera italiana

TET2 regulates mast cell differentiation and proliferation through catalytic and non-catalytic activities

Montagner, Sara ; Leoni, Cristina ; Emming, Stefan ; Della Chiara, Giulia ; Balestrieri, Chiara ; Barozzi, Iros ; Piccolo, Viviana ; Togher, Susan ; Ko, Myunggon ; Rao, Anjana ; Natoli, Gioacchino ; Monticelli, Silvia

In: Cell reports, 2016, vol. 15, no. 7, p. 1566-1579

Dioxygenases of the TET family impact genome functions by converting 5-methylcytosine (5mC) in DNA to 5-hydroxymethylcytosine (5hmC). Here, we identified TET2 as a crucial regulator of mast cell differentiation and proliferation. In the absence of TET2, mast cells showed disrupted gene expression and altered genome-wide 5hmC deposition, especially at enhancers and in the proximity of...

Università della Svizzera italiana

Epigenetics of T lymphocytes in health and disease

Leoni, Cristina ; Vincenzetti, Lucia ; Emming, Stefan ; Monticelli, Silvia

In: Swiss Medical weekly, 2015, vol. 145, p. w14191

The risk of developing autoimmune diseases depends on both genetic and environmental factors, with epigenetic mechanisms of regulation potentially translating environmental cues into stable modifications in gene expression. Such stable memory of a functional state has been deciphered into a number of molecular mechanisms that collectively define the epigenetic status of a cell. In recent years,...