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Infected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria

Mantel, Pierre-Yves ; Hjelmqvist, Daisy ; Walch, Michael ; Kharoubi-Hess, Solange ; Nilsson, Sandra ; Ravel, Deepali ; Ribeiro, Marina ; Grüring, Christof ; Ma, Siyuan ; Padmanabhan, Prasad ; Trachtenberg, Alexander ; Ankarklev, ohan ; Brancucci, Nicolas M. ; Huttenhower, Curtis ; Duraisingh, Manoj T. ; Ghiran, Ionita ; Kuo, Winston P. ; Filgueira, Luis ; Martinelli, Roberta ; Marti, Matthias

In: Nature Communications, 2016, vol. 7, p. 12727

Malaria remains one of the greatest public health challenges worldwide, particularly in sub-Saharan Africa. The clinical outcome of individuals infected with Plasmodium falciparum parasites depends on many factors including host systemic inflammatory responses, parasite sequestration in tissues and vascular dysfunction. Production of pro-inflammatory cytokines and chemokines promotes endothelial...