In: npj Quantum Materials, 2021, vol. 6, no. 1, p. 12
The interplay of nearly degenerate orders in quantum materials can lead to a myriad of emergent phases. A prominent case is that of the high-Tc cuprates for which the relationship between superconductivity and a short-ranged, incommensurate charge density wave in the CuO2 planes involving the dx2−y2 orbitals (Cu-CDW) is a subject of great current interest. Strong modifications of the...
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In: Leukemia, 2021, p. 7 p
The prognostic significance of lymphocyte doubling time (LDT) in chronic lymphocytic leukemia (CLL) was identified when the biology of the disease was poorly understood and therapy was not effective. We assessed the clinical and biological significance of LDT in 848 CLL patients in a real-life setting and the context of new biomarkers and effective therapy. A short LDT (≤12 months) was...
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In: Blood, 2020, vol. 135, no. 21, p. 1859–1869
Most patients with chronic lymphocytic leukemia (CLL) are diagnosed with early-stage disease and managed with active surveillance. The individual course of patients with early-stage CLL is heterogeneous, and their probability of needing treatment is hardly anticipated at diagnosis. We aimed at developing an international prognostic score to predict time to first treatment (TTFT) in patients...
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In: Global Change Biology, 2020//n/a/-
Predicting plant distributions under climate change is constrained by our limited understanding of potential rapid adaptive evolution. In an experimental evolution study with the invasive common ragweed (Ambrosia artemisiifolia L.) we subjected replicated populations of the same initial genetic composition to simulated climate warming. Pooled DNA sequencing of parental and offspring...
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In: Evolution Letters, 2020, vol. 4, no. 2, p. 94–108
Evolutionary processes, including selection, can be indirectly inferred based on patterns of genomic variation among contemporary populations or species. However, this often requires unrealistic assumptions of ancestral demography and selective regimes. Sequencing ancient DNA from temporally spaced samples can inform about past selection processes, as time series data allow direct...
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In: Frontiers in Ecology and Evolution, 2020, vol. 8, p. 82
Nervous systems are complex cellular structures that allow animals to interact with their environment, which includes both the external and the internal milieu. The astonishing diversity of nervous system architectures present in all animal clades has prompted the idea that selective forces must have shaped them over evolutionary time. In most cases, neurons seem to coalesce into specific ...
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In: Geologica Carpathica, 2019, vol. 70, no. 4, p. 325–354
A cyclostratigraphic interpretation of peritidal to shallow-marine ramp deposits of the early Middle Triassic (Anisian) Opletnya Member exposed in outcrops along the Iskar River gorge, NW Bulgaria, is presented. Based on facies trends and bounding surfaces, depositional sequences of several orders can be identified. New biostratigraphic data provide a time frame of the studied succession with...
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In: Cell and Tissue Research, 2019, vol. 377, no. 3, p. 369–382
Interest in the study of Xenacoelomorpha has recently been revived due to realization of its key phylogenetic position as the putative sister group of the remaining Bilateria. Phylogenomic studies have attracted the attention of researchers interested in the evolution of animals and the origin of novelties. However, it is clear that a proper understanding of novelties can only be gained in...
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In: BMC structural biology, 2016, vol. 16, p. 17
Background: TPX2 (Targeting Protein for Xklp2) is essential for spindle assembly, activation of the mitotic kinase Aurora A and for triggering microtubule nucleation. Homologs of TPX2 in Chordata and plants were previously identified. Currently, proteins of the TPX2 family have little structural information and only small parts are covered by defined protein domains. Methods: We have used ...
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In: Stratigraphy & Timescales, 2018, vol. 3, p. 151–187
The sedimentary record of ancient shallow-marine carbonate platforms commonly displays a stacking of different facies, which reflects repetitive changes of depositional environments through time. These changes can be induced by external factors such as cyclical changes in climate and/or sea level, but also by internal factors such as lateral migration of sediment bodies and/or changes in the...
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