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Neuropeptide alterations in the tree shrew hypothalamus during volatile anesthesia

Fouillen, Laetitia ; Petruzziello, Filomena ; Veit, Julia ; Bhattacharyya, Anwesha ; Kretz, Robert ; Rainer, Gregor ; Zhang, Xiaozhe

In: Journal of Proteomics, 2012, p. -

Neuropeptides are critical signaling molecules, involved in the regulation of diverse physiological processes including energy metabolism, pain perception and brain cognitive state. Prolonged general anesthesia has an impact on many of these processes, but the regulation of peptides by general anesthetics is poorly understood. In this study, we present an in-depth characterization of the...