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Statins prevent pulsatile stretch-induced proliferation of human saphenous vein smooth muscle cells via inhibition of Rho/Rho-kinase pathway

Kozai, Toshiyuki ; Eto, Masato ; Yang, Zhihong ; Shimokawa, Hiroaki ; Lüscher, Thomas F.

In: Cardiovascular Research, 2005, vol. 68, no. 3, p. 475-482

Statins prevent pulsatile stretch-induced proliferation of human saphenous vein smooth muscle cells via inhibition of Rho/Rho-kinase pathway

Kozai, Toshiyuki ; Eto, Masato ; Yang, Zhihong ; Shimokawa, Hiroaki ; Lüscher, Thomas F.

In: Cardiovascular Research, 2005, vol. 68, no. 3, p. 475-482

Objective: Pulsatile forces regulate vascular remodeling and trigger vascular diseases such as saphenous vein graft disease. The saphenous vein is exposed to high pressure and pulsatility only after implantation. Statins have been proved to reduce the incidence of vein graft failure. Thus, we investigated the molecular mechanisms of pulsatile stretch-induced saphenous vein smooth...