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No evidence for involvement of the human inducible nitric oxide synthase gene in susceptibility to coronary artery disease

Muntwyler, Jörg ; Marti-Jaun, Jacqueline ; Lüscher, Thomas F. ; Hänseler, Edgar ; Hersberger, Martin

In: Clinical Chemical Laboratory Medicine, 2005, vol. 43, no. 2, p. 253-255

Statins prevent pulsatile stretch-induced proliferation of human saphenous vein smooth muscle cells via inhibition of Rho/Rho-kinase pathway

Kozai, Toshiyuki ; Eto, Masato ; Yang, Zhihong ; Shimokawa, Hiroaki ; Lüscher, Thomas F.

In: Cardiovascular Research, 2005, vol. 68, no. 3, p. 475-482

Endothelial Regulation of Vascular Tone and Growth

Lüscher, Thomas F. ; Tanner, Felix C.

In: American Journal of Hypertension, 1993, vol. 6, no. 7_Pt_2, p. 283S-293S

17β-Estradiol inhibits proliferation and migration of human vascular smooth muscle cells: similar effects in cells from postmenopausal females and in males

Dai-Do, Do ; Espinosa, Emma ; Liu, Guizhen ; Rabelink, Ton J. ; Julmy, Friedgard ; Yang, Zhihong ; Mahler, Felix ; Lüscher, Thomas F.

In: Cardiovascular Research, 1996, vol. 32, no. 5, p. 980-985

Different vascular smooth muscle cell apoptosis in the human internal mammary artery and the saphenous vein: implications for bypass graft disease

Frischknecht, Karin ; Greutert, Helen ; Weisshaupt, Christian ; Kaspar, Mathias ; Yang, Zhihong ; Lüscher, Thomas F. ; Carrel, Thierry P. ; Tanner, Felix C.

In: Journal of Vascular Research, 2006, vol. 43, no. 4, p. 338-346

The remarkable patency of internal mammary artery (MA) grafts compared to saphenous vein (SV) grafts has been related to different biological properties of the two blood vessels. We examined whether proliferation and apoptosis of vascular smooth muscle cells (VSMC) from human coronary artery bypass vessels differ according to patency rates. Methods and Results: Proliferation rates to serum...

Statins prevent pulsatile stretch-induced proliferation of human saphenous vein smooth muscle cells via inhibition of Rho/Rho-kinase pathway

Kozai, Toshiyuki ; Eto, Masato ; Yang, Zhihong ; Shimokawa, Hiroaki ; Lüscher, Thomas F.

In: Cardiovascular Research, 2005, vol. 68, no. 3, p. 475-482

Objective: Pulsatile forces regulate vascular remodeling and trigger vascular diseases such as saphenous vein graft disease. The saphenous vein is exposed to high pressure and pulsatility only after implantation. Statins have been proved to reduce the incidence of vein graft failure. Thus, we investigated the molecular mechanisms of pulsatile stretch-induced saphenous vein smooth...

Nitric oxide synthase gene transfer inhibits biological features of bypass graft disease in the human saphenous vein

Tanner, Felix C. ; Largiadèr, Thomas ; Greutert, Helen ; Yang, Zhihong ; Lüscher, Thomas F.

In: Journal of Thoracic and Cardiovascular Surgery, 2004, vol. 127, no. 1, p. 20-26

Background Bypass graft disease is related to proliferation and migration of vascular smooth muscle cells and to platelet activation with thrombus formation. Nitric oxide inhibits these biological responses; it has never been demonstrated, however, whether this occurs in intact human vascular tissue after endothelial nitric oxide synthase gene transfer. Methods We examined whether endothelial...