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Targeting glycolysis in macrophages confers protection against pancreatic ductal adenocarcinoma

Penny, Hweixian Leong ; Sieow, Je Lin ; Gun, Sin Yee ; Lau, Mai Chan ; Lee, Bernett ; Tan, Jasmine ; Phua, Cindy ; Toh, Florida ; Nga, Yvonne ; Yeap, Wei Hseun ; Janela, Baptiste ; Kumar, Dilip ; Chen, Hao ; Yeong, Joe ; Kenkel, Justin A. ; Pang, Angela ; Lim, Diana ; Toh, Han Chong ; Hon, Tony Lim Kiat ; Johnson, Christopher I. ; Khameneh, Hanif Javanmard ; Mortellaro, Alessandra ; Engleman, Edgar G. ; Rotzschke, Olaf ; Ginhoux, Florent ; Abastado, Jean-Pierre ; Chen, Jinmiao ; Wong, Siew Cheng

In: International journal of molecular sciences, 2021, vol. 22, no. 12, p. 24

Inflammation in the tumor microenvironment has been shown to promote disease progression in pancreatic ductal adenocarcinoma (PDAC); however, the role of macrophage metabolism in promoting inflammation is unclear. Using an orthotopic mouse model of PDAC, we demonstrate that macrophages from tumor-bearing mice exhibit elevated glycolysis. Macrophage- specific deletion of Glucose Transporter 1...

Immunological aspects of atherosclerosis

Garrido-Urbani, S. ; Meguenani, M. ; Montecucco, F. ; Imhof, B.

In: Seminars in Immunopathology, 2014, vol. 36, no. 1, p. 73-91

Association between the A-2518G polymorphism in the monocyte chemoattractant protein-1 gene and insulin resistance and Type 2 diabetes mellitus

Simeoni, E. ; Hoffmann, M. ; Winkelmann, B. ; Ruiz, J. ; Fleury, S. ; Boehm, B. ; März, W. ; Vassalli, G.

In: Diabetologia, 2004, vol. 47, no. 9, p. 1574-1580

Macrophage Migration Inhibitory Factor Deficiency Is Associated With Impaired Killing of Gram-Negative Bacteria by Macrophages and Increased Susceptibility to Klebsiella pneumoniae Sepsis

Roger, Thierry ; Delaloye, Julie ; Chanson, Anne-Laure ; Giddey, Marlyse ; Le Roy, Didier ; Calandra, Thierry

In: The Journal of Infectious Diseases, 2013, vol. 207, no. 2, p. 331-339

Nitric oxide synthase 2 is required for conversion of pro-fibrogenic inflammatory CD133+ progenitors into F4/80+ macrophages in experimental autoimmune myocarditis

Blyszczuk, Przemyslaw ; Berthonneche, Corrine ; Behnke, Silvia ; Glönkler, Marcel ; Moch, Holger ; Pedrazzini, Thierry ; Lüscher, Thomas F. ; Eriksson, Urs ; Kania, Gabriela

In: Cardiovascular Research, 2013, vol. 97, no. 2, p. 219-229