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Across-night dynamics in traveling sleep slow waves throughout childhood

Schoch, Sarah F. ; Riedner, Brady A. ; Deoni, Sean C. ; Huber, Reto ; LeBourgeois, Monique K. ; Kurth, Salome

In: SLEEP, 2018, vol. 41, no. 11, p. -

Axotomized Corticospinal Neurons Increase Supra-Lesional Innervation and Remain Crucial for Skilled Reaching after Bilateral Pyramidotomy

Mosberger, Alice C. ; Miehlbradt, Jenifer C. ; Bjelopoljak, Nadja ; Schneider, Marc P. ; Wahl, Anna-Sophia ; Ineichen, Benjamin V. ; Gullo, Miriam ; Schwab, Martin E.

In: Cerebral Cortex, 2018, vol. 28, no. 2, p. 625-643

Asymmetric and distant effects of a unilateral lesion of the primary motor cortex on the bilateral supplementary motor areas in adult macaque monkeys

Contestabile, Alessandro. ; Colangiulo, R. ; Lucchini, Matteo ; Gindrat, Anne-Dominique ; Hamadjida, Adjia ; Kaeser, Mélanie ; Savidan, Julie ; Wyss, A. F. ; Rouiller, Eric M. ; Schmidlin, Eric

In: Journal of Neuroscience, 2018, vol. 38, no. 50, p. 10644–10656

A restricted lesion of the hand area in the primary motor cortex (M1) leads to a deficit of contralesional manual dexterity, followed by an incomplete functional recovery, accompanied by plastic changes in M1 itself and in other cortical areas on both hemispheres. Using the marker SMI-32 specific to pyramidal neurons in cortical layers III and V, we investigated the impact of a focal...

Back seat driving: hindlimb corticospinal neurons assume forelimb control following ischaemic stroke

Starkey, Michelle Louise ; Bleul, Christiane ; Zörner, Björn ; Lindau, Nicolas Thomas ; Mueggler, Thomas ; Rudin, Markus ; Schwab, Martin Ernst

In: Brain, 2012, vol. 135, no. 11, p. 3265-3281

Age-related differences in corticospinal excitability during observation and motor imagery of balance tasks

Mouthon, Audrey A. ; Ruffieux, Jan ; Keller, Martin ; Taube, Wolfgang

In: Frontiers in Aging Neuroscience, 2016, vol. 8, p. -

Postural control declines across adult lifespan. Non-physical balance training has been suggested as an alternative to improve postural control in frail/immobilized elderly people. Previous studies showed that this kind of training can improve balance control in young and older adults. However, it is unclear whether the brain of young and older adults is activated differently during mental...

Autologous adult cortical cell transplantation enhances functional recovery following unilateral lesion of motor cortex in primates: a pilot study

Kaeser, Melanie ; Brunet, Jean-Francois ; Wyss, Alexander ; Belhaj-Saif, Abderraouf ; Liu, Yu ; Hamadjida, Adjia ; Rouiller, Eric M. ; Bloch, Jocelyne

In: Neurosurgery, 2011, vol. 68, no. 5, p. 1405-1417

BACKGROUND: Although cell therapy is a promising approach after cerebral cortex lesion, few studies assess quantitatively its behavioral gain in nonhuman primates. Furthermore, implantations of fetal grafts of exogenous stem cells are limited by safety and ethical issues.OBJECTIVE: To test in nonhuman primates the transplantation of autologous adult neural progenitor cortical cells with...

Anti-Nogo-A antibody treatment enhances functional recovery and sprouting of the corticospinal tract after spinal cord injury in adult primates

Freund, Patrick ; Wannier, Thierry (Dir.)

Thèse de doctorat : Université de Fribourg, 2008 ; Nr. 1592.

After injury to the adult central nervous system (CNS), permanent deficits remain to a large part due to limited cell renewal, axonal regeneration and reestablishment of functional connectivity. Evidence indicate that the lack of axonal regeneration is partly due to the myelin-associated inhibitory factor Nogo-A. A therapeutical strategy to overcome this inhibition is to prevent the neurite...

Anti-Nogo-A antibody treatment promotes recovery of manual dexterity after unilateral cervical lesion in adult primates – re-examination and extension of behavioral data

Freund, Patrick ; Schmidlin, Eric ; Wannier, Thierry ; Bloch, Jocelyne ; Mir, Anis ; Schwab, Martin E. ; Rouiller, Eric M.

In: European Journal of Neuroscience, 2009, vol. 29, no. 5, p. 983 - 996

In rodents and nonhuman primates subjected to spinal cord lesion, neutralizing the neurite growth inhibitor Nogo-A has been shown to promote regenerative axonal sprouting and functional recovery. The goal of the present report was to re-examine the data on the recovery of the primate manual dexterity using refined behavioral analyses and further statistical assessments, representing secondary...

Anti-Nogo-A antibody treatment does not prevent cell body shrinkage in the motor cortex in adult monkeys subjected to unilateral cervical cord lesion

Beaud, Marie-Laure ; Schmidlin, Eric ; Wannier, Thierry ; Freund, Patrick ; Bloch, Jocelyne ; Mir, Anis ; Schwab, Martin E. ; Rouiller, Eric M.

In: BMC Neuroscience, 2008, vol. 9, no. 1, p. 5

Background: After unilateral cervical cord lesion at the C7/C8 border interrupting the dorsolateral funiculus in adult monkeys, neutralization of Nogo-A using a specific monoclonal antibody promoted sprouting of corticospinal (CS) axons rostral and caudal to the lesion and, in parallel, improved functional recovery. In monkeys lesioned but not treated with the anti-Nogo-A antibody, the CS neurons...

Anti-Nogo-A antibody treatment enhances sprouting of corticospinal axons rostral to a unilateral cervical spinal cord lesion in adult macaque monkey

Freund, Patrick ; Wannier, Thierry ; Schmidlin, Eric ; Bloch, Jocelyne ; Mir, Anis ; Schwab, Martin E. ; Rouiller, Eric M.

In: The Journal of Comparative Neurology, 2007, vol. 502, no. 4, p. 644 - 659

After injury, regrowth of axons in mammalian adult central nervous system is highly limited. However, in monkeys subjected to unilateral cervical lesion (C7-C8 level), neutralization of an important neurite outgrowth inhibitor, Nogo-A, stimulated axonal sprouting caudal to the lesion, accompanied by enhanced functional recovery of manual dexterity, compared with lesioned monkeys treated with a...