In: Bioinformatics, 2018, vol. 34, no. 14, p. 2483-2484
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In: International Journal of Molecular Sciences, 2020, vol. 21, no. 12, p. 4441
In recent years, immunotherapy has become the most promising therapy for a variety of cancer types. The development of immune checkpoint blockade (ICB) therapies, the adoptive transfer of tumor-specific T cells (adoptive cell therapy (ACT)) or the generation of T cells engineered with chimeric antigen receptors (CAR) have been successfully applied to elicit durable immunological responses in...
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In: Cell reports, 2018, vol. 23, no. 1, p. 39-49
In chronic infection and cancer, T cells acquire a dysfunctional state characterized by the expression of inhibitory receptors. In vitro studies implicated the phosphatase Shp-2 downstream of these receptors, including PD-1. However, whether Shp-2 is responsible in vivo for such dysfunctional responses remains elusive. To address this, we generated T cell- specific Shp-2-deficient mice. These...
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In: Oncogene, 2019, vol. 38, no. 15, p. 2814–2829
Neoadjuvant and adjuvant chemotherapies provide survival benefits to breast cancer patients, in particular in estrogen receptor negative (ER−) cancers, by reducing rates of recurrences. It is assumed that the benefits of (neo)adjuvant chemotherapy are due to the killing of disseminated, residual cancer cells, however, there is no formal evidence for it. Here, we provide experimental...
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Thèse de doctorat : Università della Svizzera italiana, 2019 ; 2019INFO003.
Services rely on replication mechanisms to be available at all time. The service demanding high availability is replicated on a set of machines called replicas. To maintain the consistency of replicas, a consensus protocol such as Paxos or Raft is used to synchronize the replicas' state. As a result, failures of a minority of replicas will not affect the service as other non-faulty replicas...
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In: Cellular and Molecular Life Sciences CMLS, 2003, vol. 60, no. 10, p. 2254-2265
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In: Journal of Mammary Gland Biology and Neoplasia, 2003, vol. 8, no. 3, p. 269-285
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In: Journal of Mammary Gland Biology and Neoplasia, 2006, vol. 11, no. 3-4, p. 239-248
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In: Cellular and Molecular Life Sciences, 2007, vol. 64, no. 21, p. 2746-2762
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In: Cellular and Molecular Life Sciences, 2008, vol. 65, no. 6, p. 1005-1005
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