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Université de Fribourg

Treatment evaluation in the presence of sample selection

Huber, Martin

In: Econometric reviews, 2014, vol. 33, no. 8, p. 869-905

Sample selection and attrition are inherent in a range of treatment evaluation problems such as the estimation of the returns to schooling or training. Conventional estimators tackling selection bias typically rely on restrictive functional form assumptions that are unlikely to hold in reality. This paper shows identification of average and quantile treatment effects in the presence of the...

Università della Svizzera italiana

HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4

Schiraldi, Milena ; Raucci, Angela ; Martínez Muñoz, Laura ; Livoti, Elsa ; Celona, Barbara ; Venereau, Emilie ; Apuzzo, Tiziana ; De Marchis, Francesco ; Pedotti, Mattia ; Bachi, Angela ; Thelen, Marcus ; Varani, Luca ; Mellado, Mario ; Proudfoot, Amanda ; Bianchi, Marco Emilio ; Uguccioni, Mariagrazia

In: The journal of experimental medicine, 2012, vol. 209, no. 3, p. 551-563

After tissue damage, inflammatory cells infiltrate the tissue and release proinflammatory cytokines. HMGB1 (high mobility group box 1), a nuclear protein released by necrotic and severely stressed cells, promotes cytokine release via its interaction with the TLR4 (Toll-like receptor 4) receptor and cell migration via an unknown mechanism. We show that HMGB1- induced recruitment of inflammatory...

Università della Svizzera italiana

The protein disulfide isomerase ERp57 regulates the steady-state levels of the prion protein

Torres, Mauricio ; Medinas,Danilo B. ; Matamala, José Manuel ; Woehlbier, Ute ; Cornejo, Víctor Hugo ; Solda, Tatiana ; Andreu, Catherine ; Rozas, Pablo ; Matus, Soledad ; Muñoz, Natalia ; Vergara, Carmen ; Cartier, Luis ; Soto, Claudio ; Molinari, Maurizio ; Hetz, Claudio

In: The journal of biological chemistry, 2015, vol. 290, no. 39, p. 23631-23645

Although the accumulation of a misfolded and protease-resistant form of the prion protein (PrP) is a key event in Prion pathogenesis, the cellular factors involved in its folding and quality control are poorly understood. PrP is a glycosylated and disulfide-bonded protein synthesized at the endoplasmic reticulum (ER). The ER foldase ERp57 (also known as Grp58) is highly expressed in the brain...

Université de Fribourg

Toolbox for in vivo imaging of host–parasite interactions at multiple scales

Niz, Mariana De ; Spadin, Florentin ; Marti, Matthias ; Stein, Jens V. ; Frenz, Martin ; Frischknecht, Friedrich

In: Trends in Parasitology, 2019, vol. 35, no. 3, p. 193–212

Animal models have for long been pivotal for parasitology research. Over the last few years, techniques such as intravital, optoacoustic and magnetic resonance imaging, optical projection tomography, and selective plane illumination microscopy developed promising potential for gaining insights into host–pathogen interactions by allowing different visualization forms in vivo and ex vivo....

Université de Fribourg

Size and shape: the developmental regulation of static allometry in insects

Shingleton, Alexander W. ; Frankino, W. Anthony ; Flatt, Thomas ; Nijhout, H. Frederik ; Emlen, Douglas J.

In: BioEssays, 2007, vol. 29, no. 6, p. 536-548

Among all organisms, the size of each body part or organ scales with overall body size, a phenomenon called allometry. The study of shape and form has attracted enormous interest from biologists, but the genetic, developmental and physiological mechanisms that control allometry and the proportional growth of parts have remained elusive. Recent progress in our understanding of body‐size...

Université de Fribourg

DNA metabarcoding reveals changes in the contents of carnivorous plants along an elevation gradient

Littlefair, Joanne E. ; Zander, Axel ; Sena Costa, Clara de ; Clare, Elizabeth L.

In: Molecular Ecology, 2019, vol. 28, no. 2, p. 281–292

Resource variation along abiotic gradients influences subsequent trophic interactions and these effects can be transmitted through entire food webs. Interactions along abiotic gradients can provide clues as to how organisms will face changing environmental conditions, such as future range shifts. However, it is challenging to find replicated systems to study these effects. Phytotelmata, such...

Université de Fribourg

Hematological analysis of the ascidian Botrylloides leachii (Savigny, 1816) during whole-body regeneration

Blanchoud, Simon ; Zondag, Lisa ; Lamare, Miles D. ; Wilson, Megan J.

In: The Biological Bulletin, 2017, vol. 232, no. 3, p. 143–157

Whole-body regeneration (WBR)—the formation of an entire adult from only a small fragment of its own tissue—is extremely rare among chordates. Exceptionally, in the colonial ascidian Botrylloides leachii (Savigny, 1816) a fully functional adult is formed from their common vascular system after ablation of all adults from the colony in just 10 d, thanks to their high blastogenetic...

Université de Fribourg

Theory of photoinduced ultrafast switching to a spin-orbital ordered hidden phase

Li, Jiajun ; Strand, Hugo U.R. ; Werner, Philipp ; Eckstein, Martin

In: Nature Communications, 2018, vol. 9, no. 1, p. 4581

Photo-induced hidden phases are often observed in materials with intertwined orders. Understanding the formation of these non-thermal phases is challenging and requires a resolution of the cooperative interplay between different orders on the ultra-short timescale. In this work, we demonstrate that non-equilibrium photo-excitations can induce a state with spin-orbital orders entirely...

Université de Fribourg

Downslope-shifting pockmarks: interplay between hydrocarbon leakage, sedimentations, currents and slope’s topography

Ho, Sutieng ; Imbert, Patrice ; Hovland, Martin ; Wetzel, Andreas ; Blouet, Jean-Philippe ; Carruthers, Daniel

In: International Journal of Earth Sciences, 2018, vol. 107, no. 8, p. 2907–2929

Pockmarks in Pliocene-Quaternary continental slope deposits offshore Angola show features related to: (1) fluid leakage craters that formed repeatedly, (2) authigenic methane-derived carbonates that indicate the (former) presence of hydrocarbons and (3) erosional–depositional structures that are clearly related to current activity. Depending on topography, the pockmarks show differing...

Université de Fribourg

Solid-state structure and anti­microbial and cytotoxicity studies of a cucurbit[6]uril-like Cu6L4 constructed from 3,5-bis­[(1H-tetra­zol-5-yl)meth­yl]-4H-1,2,4-triazol-4-amine

Vasylevskyi, Serhii ; Holzheu, Anja ; Fromm, Katharina M.

In: Acta Crystallographica Section C: Structural Chemistry, 2018, vol. 74, no. 11, p. 1413–1419

3,5-Bis[(1H-tetra­zol-5-yl)meth­yl]-4H-1,2,4-triazol-4-amine (H2L) associates under deprotonation with CuSO4 in aqueous medium to form a new waisted barrel-shaped M6L4 cluster, namely hexa­aqua­tetra­kis­{μ4-3,5-bis­[(1H-tetra­zol-5-yl)meth­yl]-4H-1,2,4- triazol-4-amine}-μ4-sulfato-hexa­copper(II) sulfate hydrate, [Cu6(SO4) (C6H6N12)4(H2O)6]SO4·nH2O (n = ∼23) (1). Cluster 1...