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Università della Svizzera italiana

Selective preservation of bone marrow mature recirculating but not marginal zone B cells in murine models of chronic inflammation

Traggiai, Elisabetta ; Casati, Anna ; Frascoli, Michela ; Porcellini, Simona ; Ponzoni, Maurilio ; Sanvito, Francesca ; Leng, Lin ; Bucala, Richard ; Moretta, Lorenzo ; Grassi, Fabio

In: Plos one, 2010, vol. 5, no. 6, p. e11262

Inflammation promotes granulopoiesis over B lymphopoiesis in the bone marrow (BM). We studied B cell homeostasis in two murine models of T cell mediated chronic inflammation, namely calreticulin-deficient fetal liver chimeras (FLC), which develop severe blepharitis and alopecia due to T cell hyper responsiveness, and inflammatory bowel disease (IBD) caused by injection of CD4+ naïve T cells...