Université de Fribourg

Application of photoclick chemistry for the synthesis of pyrazoles via 1,3‐dipolar cycloaddition between alkynes and nitrilimines generated in situ

Remy, Richard ; Bochet, Christian G.

In: European Journal of Organic Chemistry, 2018, vol. 2018, no. 3, p. 316–328

The photochemical extrusion of gaseous nitrogen from 2,5-disubstituted tetrazoles to generate reactive nitrilimines in situ represents an efficient and attractive way to form dipoles that can be used to provide useful chemicals via 1,3-dipolar cycloadditions. The concept of “photoclick chemistry” already inspired numerous researchers, who exploited photochemical processes involving...

Université de Neuchâtel

Malonylation/Decarbalkoxylation of Furan Derivatives as Key Steps for the Preparation of Nonactic Acid Derivatives. Part I [1]

Simone, Jean-Mary ; Loiseau, François ; Carcache, David ; Bobal, Pavel ; Jeanneret-Gris, Julie ; Neier, Reinhard

In: Monatshefte für Chemie / Chemical Monthly, 2007, vol. 138, no. 2, p. 131-139

A malonylation/decarbalkoxylation sequence from 2-substituted furans was investigated in view of developing a scalable synthesis of hydrophobic nonactic acid analogues.

Université de Neuchâtel

Macrocyclisation of 2-(5-(2-hydroxyethyl)furan-2-yl)acetic acid model compounds of nonactic acid

Eng, Carine ; Simone, Jean-Mary ; Hartenbach, Akane ; Loiseau, François ; Neier, Reinhard

In: Monatshefte für Chemie / Chemical Monthly, 2009, vol. 140, no. 3, p. 349-354

The macrocyclisation of hydroxyethylfuranyl acetic acid and of dehydrogenated model compounds of nonactic acid was investigated to develop a facile synthesis of nonactin analogues. By applying the Yamagushi macrocyclisation to our ω-hydroxyacids, we were able to isolate a mixture of di-, tri-, tetra- and pentameric macrocycles.

Université de Neuchâtel

Malonylation/Decarbalkoxylation of Furan Derivatives as Key Steps for the Preparation of Nonactic Acid Derivatives. Part II [1]

Simone, Jean-Mary ; Loiseau, François ; Carcache, David ; Bobal, Pavel ; Jeanneret-Gris, Julie ; Neier, Reinhard

In: Monatshefte für Chemie / Chemical Monthly, 2007, vol. 138, no. 2, p. 141-147

A malonylation/decarbalkoxylation sequence from 2-substituted furans was investigated in view of developing a scalable synthesis of hydrophobic nonactic acid analogues.