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Université de Fribourg

Evolution in group-structured populations can resolve the tragedy of the commons

Killingback, Timothy ; Bieri, Jonas ; Flatt, Thomas

In: Proceeding of the Royal Society, 2006, no. 273, p. 1477–1481

Public goods are the key features of all human societies and are also important in many animal societies. Collaborative hunting and collective defence are but two examples of public goods that have played a crucial role in the development of human societies and still play an important role in many animal societies. Public goods allow societies composed largely of cooperators to outperform...

Università della Svizzera italiana

How viruses hijack the ERAD tuning machinery

Noack, Julia ; Bernasconi, Riccardo ; Molinari, Maurizio

In: Journal of virology, 2014, vol. 88, no. 18, p. 10272-10275

An essential step during the intracellular life cycle of many positive-strand RNA viruses is the rearrangement of host cell membranes to generate membrane-bound replication platforms. For example, Nidovirales and Flaviviridae subvert the membrane of the endoplasmic reticulum (ER) for their replication. However, the absence of conventional ER and secretory pathway markers in virus-induced...

Università della Svizzera italiana

Division of labor among oxidoreductases : TMX1 preferentially acts on transmembrane polypeptides

Brambilla Pisoni, Giorgia ; Ruddock, Lloyd W. ; Bulleid, Neil ; Molinari, Maurizio

In: Molecular biology of the cell, 2015, vol. 26, no. 19, p. 3373-3556

The endoplasmic reticulum (ER) is the site of maturation for secretory and membrane proteins in eukaryotic cells. The lumen of the mammalian ER contains >20 members of the protein disulfide isomerase (PDI) superfamily, which ensure formation of the correct set of intramolecular and intermolecular disulfide bonds as crucial, rate-limiting reactions of the protein folding process. Components of...

Université de Fribourg

Remote sensing of cropping practice in Northern Italy using time-series from Sentinel-2

Ottosen, Thor-Bjørn ; Lommen, Suzanne T.E. ; Skjøth, Carsten Ambelas

In: Computers and Electronics in Agriculture, 2019, vol. 157, p. 232–238

Maps of cropping practice, including the level of weed infestation, are useful planning tools e.g. for the assessment of the environmental impact of the crops, and Northern Italy is an important example due to the large and diverse agricultural production and the high weed infestation. Sentinel-2A is a new satellite with a high spatial and temporal resolution which potentially allows the...

Université de Fribourg

The metalloprotease ADAMTS4 generates N-truncated Aβ4–x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer’s disease

Walter, Susanne ; Jumpertz, Thorsten ; Hüttenrauch, Melanie ; Ogorek, Isabella ; Gerber, Hermeto ; Storck, Steffen E. ; Zampar, Silvia ; Dimitrov, Mitko ; Lehmann, Sandra ; Lepka, Klaudia ; Berndt, Carsten ; Wiltfang, Jens ; Becker-Pauly, Christoph ; Beher, Dirk ; Pietrzik, Claus U. ; Fraering, Patrick C. ; Wirths, Oliver

In: Acta Neuropathologica, 2019, vol. 137, no. 2, p. 239–257

Brain accumulation and aggregation of amyloid-β (Aβ) peptides is a critical step in the pathogenesis of Alzheimer’s disease (AD). Full-length Aβ peptides (mainly Aβ1–40 and Aβ1–42) are produced through sequential proteolytic cleavage of the amyloid precursor protein (APP) by β- and γ-secretases. However, studies of autopsy brain samples from AD patients have demonstrated that a...

Université de Neuchâtel

El ritmo acentual en treinta y tres romances de juventud atribuidos a Lope de Vega

Llamas Martínez, Jacobo ; Sánchez Jiménez, Antonio (Dir.) ; Matas Caballero, Juan (Codir.) ; Navarro Colorado, Borja (Codir.) ; Udaondo Alegre, Juan (Codir.)

Thèse de doctorat : Université de Neuchâtel, 2019.

Cette thèse est basée sur une affirmation de Lope dans le prologue des Rimas de 1604 sur la «corresponsión de las cadencias » de ses romances ; la déclaration semble faire référence à une difficulté technique liée à la distribution des accents et dans laquelle les « gente ignorante » ne réparent généralement pas. Pour résoudre les deux questions, si Lope a fait allusion à une...

Università della Svizzera italiana

Homeostatic expansion of autoreactive immunoglobulin-secreting cells in the Rag2 mouse model of Omenn syndrome

Cassani, Barbara ; Poliani, Pietro Luigi ; Marrella, Veronica ; Schena, Francesca ; Sauer, Aisha V. ; Ravanini, Maria ; Strina, Dario ; Busse, Christian E. ; Regenass, Stephan ; Wardemann, Hedda ; Martini, Alberto ; Facchetti, Fabio ; Burg, Mirjam van der ; Rolink, Antonius G. ; Vezzoni, Paolo ; Grassi, Fabio ; Traggiai, Elisabetta ; Villa, Anna

In: Journal of experimental medicine, 2010, vol. 207, no. 7, p. 1525-1540

Hypomorphic RAG mutations, leading to limited V(D)J rearrangements, cause Omenn syndrome (OS), a peculiar severe combined immunodeficiency associated with autoimmune-like manifestations. Whether B cells play a role in OS pathogenesis is so far unexplored. Here we report the detection of plasma cells in lymphoid organs of OS patients, in which circulating B cells are undetectable. Hypomorphic...

Université de Fribourg

A resazurin reduction-based assay for rapid detection of polymyxin resistance in Acinetobacter baumannii and Pseudomonas aeruginosa

Lescat, Mathilde ; Poirel, Laurent ; Tinguely, Camille ; Nordmann, Patrice

In: Journal of Clinical Microbiology, 2018, p. -

A rapid test was developed for identification of polymyxin resistance in non-fermenting bacteria. This test detects viable cells after growth in a medium containing a defined concentration of colistin. The principle of this test is based on the visual detection of the reduction of the resazurin reagent, a viability colorant, observed by its color change (blue to purple or pink). Its...

Université de Fribourg

Comparative study of nonequilibrium insulator-to-metal transitions in electron-phonon systems

Sayyad, Sharareh ; Žitko, Rok ; Strand, Hugo U. R. ; Werner, Philipp ; Golež, Denis

In: Physical Review B, 2019, vol. 99, no. 4, p. 045118

We study equilibrium and nonequilibrium properties of electron-phonon systems described by the Hubbard-Holstein model using dynamical mean-field theory. In equilibrium, we benchmark the results for impurity solvers based on the one-crossing approximation and slave-rotor approximation against non-perturbative numerical renormalization group reference data. We also examine how well the...

Université de Fribourg

Predicting perceptions of the lexical richness of short French, German, and Portuguese texts using text-based indices

Vanhove, Jan ; Bonvin, Audrey ; Lambelet, Amelia ; Berthele, Raphael

In: Journal of Writing Research, 2019, vol. 10, no. 3, p. 499-525

We investigated how well readers’ perceptions of the lexical richness of short texts can be predicted on the basis of automatically computable indices of the texts’ lexical properties. 3,060 French, German and Portuguese texts (between 9 and 284 words long) written by 8- to 10-year-olds were rated for their lexical richness by between 3 and 18 uninstructed raters, and over 150 indices were...