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    Université de Fribourg

    Uninephrectomy-induced lipolysis and low-grade inflammation are mimicked by unilateral renal denervation

    Arsenijevic, Denis ; Cajot, Jean-François ; Fellay, Benoit ; Dulloo, Abdul G. ; Vliet, Bruce N. Van ; Montani, Jean-Pierre

    In: Integrative Physiology, 2016, p. 227

    Uninephrectomy (UniNX) in rats on a fixed food intake leads to increased lipolysis and a low-grade inflammation with an increased subset of circulating cytokines. Because UniNX ablates renal nerves on the side of the removed kidney, we tested the contribution of unilateral renal denervation in the phenotype of UniNX. We compared Sham-operated controls, left nephrectomy (UniNX) and unilateral...

    Université de Fribourg

    Targeting arginase-II protects mice from high-fat-diet-induced hepatic steatosis through suppression of macrophage inflammation

    Liu, Chang ; Rajapakse, Angana G. ; Riedo, Erwin ; Fellay, Benoit ; Bernhard, Marie-Claire ; Montani, Jean-Pierre ; Yang, Zhihong ; Ming, Xiu-Fen

    In: Scientific Reports, 2016, vol. 6, p. 20405

    Nonalcoholic fatty liver disease (NAFLD) associates with obesity and type 2 diabetes. Hypoactive AMP-activated protein kinase (AMPK), hyperactive mammalian target of rapamycin (mTOR) signaling, and macrophage-mediated inflammation are mechanistically linked to NAFLD. Studies investigating roles of arginase particularly the extrahepatic isoform arginase-II (Arg-II) in...