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Ethanol self-administration and reinstatement of ethanol-seeking behavior in Per1Brdm1 mutant mice

Zghoul, Tarek ; Abarca, Carolina ; Sanchis-Segura, Carles ; Albrecht, Urs ; Schumann, Gunter ; Spanagel, Rainer

In: Psychopharmacology, 2007, vol. 190, no. 1, p. 13-19

Rationale Alcohol consumption shows circadian rhythmicity, i.e., alcohol preference and intake change with circadian time. Circadian rhythmicity is controlled by a biological clock, which has been shown to govern behavioral, physiological, and hormonal processes in synchronization with internal as well as external cues. Molecular components of the clock include circadian clock genes such as...