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Université de Fribourg

Targeting the extra-cellular matrix—tumor cell crosstalk for anti-cancer therapy: emerging alternatives to integrin inhibitors

Lorusso, Girieca ; Rüegg, Curzio ; Kuonen, François

In: Frontiers in Oncology, 2020, vol. 10, p. -

The extracellular matrix (ECM) is a complex network composed of a multitude of different macromolecules. ECM components typically provide a supportive structure to the tissue and engender positional information and crosstalk with neighboring cells in a dynamic reciprocal manner, thereby regulating tissue development and homeostasis. During tumor progression, tumor cells commonly modify and...

  • Yin T, Wang G, He S, Liu Q, Sun J, Wang Y....
  • Song N, Guo H, Ren J, Hao S, Wang X....
  • Yeh YC, Wang CZ, Tang MJ....
Université de Fribourg

DNA origami as emerging technology for the engineering of fluorescent and plasmonic-based biosensors

Loretan, Morgane ; Domljanovic, Ivana ; Lakatos, Mathias ; Rüegg, Curzio ; Acuna, Guillermo P.

In: Materials, 2020, vol. 13, no. 9, p. 2185

DNA nanotechnology is a powerful and promising tool for the development of nanoscale devices for numerous and diverse applications. One of the greatest potential fields of application for DNA nanotechnology is in biomedicine, in particular biosensing. Thanks to the control over their size, shape, and fabrication, DNA origami represents a unique opportunity to assemble dynamic and complex...

  • Zhan, P.; Wen, T.; Wang, Z.; He, Y.; Shi, J.; Wang, T.; Liu, X.; Lu, G.; Ding, B....
  • Shen, X.; Song, C.; Wang, J.; Shi, D.; Wang, Z.; Liu, N.; Ding, B....
  • Wang, W.; Yu, S.; Huang, S.; Bi, S.; Han, H.; Zhang, J....
Université de Fribourg

Detection of HER2+ breast cancer cells using bioinspired DNA-based signal amplification

Rafiee, Sarah D. ; Kocabey, Samet ; Mayer, Michael ; List, Jonathan ; Rüegg, Curzio

In: ChemMedChem, 2020, vol. 15, no. 8, p. 661-666

Circulating tumor cells (CTC) are promising biomarkers for metastatic cancer detection and monitoring progression. However, detection of CTCs remains challenging due to their low frequency and heterogeneity. Herein, we report a bioinspired approach to detect individual cancer cells, based on a signal amplification cascade using a programmable DNA hybridization chain reaction (HCR) circuit. We...

  • Wang, Y....
  • Wang, D....
  • Wang, G....
Université de Fribourg

Are integrins still practicable targets for anti-cancer therapy?

Alday-Parejo, Begoña ; Stupp, Roger ; Rüegg, Curzio

In: Cancers, 2019, vol. 11, no. 7, p. 978

Correlative clinical evidence and experimental observations indicate that integrin adhesion receptors, in particular those of the αV family, are relevant to cancer cell features, including proliferation, survival, migration, invasion, and metastasis. In addition, integrins promote events in the tumor microenvironment that are critical for tumor progression and metastasis, including tumor...

  • .; Wang, Z....
  • Liu, Z.; Wang, F.; Chen, X....
  • Liu, Z.; Wang, F....
Université de Fribourg

Baicalein inhibits acinar-to-ductal metaplasia of pancreatic acinal cell AR42J via improving the inflammatory microenvironment

Pu, Wei-Ling ; Luo, Ying-Ying ; Bai, Ru-Yu ; Guo, Ao-Wei ; Zhou, Kun ; Zhang, Yun-Sha ; Miao, Lin ; Rüegg, Curzio ; Hottiger, Micheal O. ; Gao, Xiu-Mei ; Sun, Li-Kang

In: Journal of Cellular Physiology, 2018, vol. 233, no. 8, p. 5747–5755

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers. Recent research has demonstrated that chronic pancreatitis (CP) is associated with an increased risk of PDAC, partly due to acinar-to-ductal metaplasia (ADM). Baicalein has been shown to exert anti-inflammatory and anti-tumor effects for CP or PDAC, respectively. The aim of our study was to investigate the effect...

  • ., Wang, X., Huang, T., Li, S., . . ....
  • Fan, G., Zhang, Y., Jiang, X., Zhu, Y., Wang, B., Cao, W., . . ....
  • He, K., Yu, X., Wang, X., Tang, L., Cao, Y., Xia, J., & Cheng, J. (2017)....
Université de Fribourg

Targeting tumor-associated macrophages by anti-tumor Chinese materia medica

Pu, Wei-ling ; Sun, Li-kang ; Gao, Xiu-mei ; Rüegg, Curzio ; Cuendet, Muriel ; Hottiger, Micheal O. ; Zhou, Kun ; Miao, Lin ; Zhang, Yun-sha ; Gebauer, Margaret

In: Chinese Journal of Integrative Medicine, 2017, vol. 23, no. 10, p. 723–732

Tumor-associated macrophages (TAMs) play a key role in all stages of tumorigenesis and tumor progression. TAMs secrete different kinds of cytokines, chemokines, and enzymes to affect the progression, metastasis, and resistance to therapy depending on their state of reprogramming. Therapeutic benefit in targeting TAMs suggests that macrophages are attractive targets for cancer treatment....

  • Wang Y....
  • Wang X....
  • Cai Z, Li W, Wang H, Yan WQ, Zhou YL, Wang GJ, et al....
Université de Fribourg

PKB/Akt-dependent regulation of inflammation in cancer

Tang, Fengyuan ; Wang, , Yuhua ; Hemmings, Brian A. ; Rüegg, Curzio ; Xue, Gongda

In: Seminars in Cancer Biology, 2017, p. -

Chronic inflammation is a major cause of human cancer. Clinical cancer therapies against inflammatory risk factors are strategically determined. To rationally guide a novel drug development, an improved mechanistic understanding on the pathological connection between inflammation and carcinogenesis is essential. PI3K-PKB signaling axis has been extensively studied and shown to be one of the...

  • Wang, Z....
  • Wang, J....
  • Wang, J....
Université de Fribourg

The matricellular protein CYR61 promotes breast cancer lung metastasis by facilitating tumor cell extravasation and suppressing anoikis

Huang, Yu-Ting ; Lan, Qiang ; Lorusso, Girieca ; Duffey, Nathalie ; Rüegg, Curzio

In: Oncotarget, 2016, vol. 8, no. 6, p. 9200–9215

Matricellular proteins play multiple roles in primary tumor growth, local invasion and tumor angiogenesis. However, their contribution to metastasis and the putative mechanisms involved are less well characterized. In ER-negative human breast cancer, elevated expression levels of the matricellular protein Cysteine-rich angiogenic inducer 61 (CYR61) are associated with more aggressive...

  • Feng P, Wang B, Ren EC....
  • Lin J, Huo R, Wang L, Zhou Z, Sun Y, Shen B, Wang R, Li N....
  • Sun ZJ, Wang Y, Cai Z, Chen PP, Tong XJ, Xie D....
Université de Fribourg

The matricellular protein CYR61 interferes with normal pancreatic islets architecture and promotes pancreatic neuroendocrine tumor progression

Huang, Yu-Ting ; Lan, Qiang ; Ponsonnet, Lionel ; Blanquet, Marisa ; Christofori, Gerhard ; Zaric, Jelena ; Rüegg, Curzio

In: Oncotarget, 2015, vol. 7, no. 2, p. 1663–1674

The significance of matricellular proteins during development and cancer progression is widely recognized. However, how these proteins actively contribute to physiological development and pathological cancer progression is only partially elucidated. In this study, we investigated the role of the matricellular protein Cysteine-rich 61 (CYR61) in pancreatic islet development and carcinogenesis....

  • Xie D, Nakachi K, Wang H, Elashoff R, Koeffler HP....
  • Xie D, Yin D, Wang HJ, Liu GT, Elashoff R, Black K, Koeffler HP....
  • Feng P, Wang B, Ren EC....
Université de Fribourg

Identification of MAGI1 as a tumor-suppressor protein induced by cyclooxygenase-2 inhibitors in colorectal cancer cells

Zaric, J. ; Joseph, J.-M. ; Tercier, S. ; Sengstag, T. ; Ponsonnet, L. ; Delorenzi, M. ; Rüegg, Curzio

In: Oncogene, 2012, vol. 31, p. 48-59

Cyclooxyganase-2 (COX-2), a rate-limiting enzyme in the prostaglandin synthesis pathway, is overexpressed in many cancers and contributes to cancer progression through tumor cell-autonomous and paracrine effects. Regular use of non-steroidal anti-inflammatory drugs or selective COX-2 inhibitors (COXIBs) reduces the risk of cancer development and progression, in particular of the colon. The COXIB...

  • COX-2 also cross-talks with the Wnt pathway (Wang et al., 2004)....
  • Wang D, Dubois RN. (2006)....
  • Wang D, Mann JR, DuBois RN. (2004)....