In: American Journal of Hypertension, 1999, vol. 12, no. S3, p. 423-426
- Long-Term Ouabain Infusion in
Long-Evans Rats
Jingli Wang, Aldo Tempini, Bvuno Scknydev, and Jean-Pierre Montani
We tested whether
ouabain, an inhibitor
of the
sodium pump, can lead to chronic hypertension
in
Long-Evans
rats using sensitive 24-h measurements
of blood pressure....
- ouabain,
sodium
pump,
0895-7061/99/$20.00
PII SO895-7061(98)00250-7
424
WANG
ET AL
AfH-MARCH
a procedure that reduces the kidney’s ability to excrete
salt and water, can potentiate the pressor effect of
ouabain....
- Some authors have
reported that Long-Evans rats are less sensitive to
certain hypertensive agents, such as chronic cold exposure14 and sucrose loading.15 However, uninephrectomy increases blood pressure markedly during
sucrose loading.15 Furthermore, Long-Evans rats do
not seem to be resistant to mineralocorticoid-induced
hypertension, as mineralocorticoid
administration
426
WANG
AJH-MARCH
ET AL
leads to similar increases in blood pressure in LongEvans rats, compared
with Sprague Dawley
rats.i6
Nevertheless,
we cannot exclude the possibility
that
Long-Evans rats may have a different distribution
of (Y
isoforms of the sodium pump in comparison
to other
rat species....
|
In: American Journal of Hypertension, 1999, vol. 12, no. 4, p. 423-426
- AJH
1999;12:423– 426
Regulation of Blood Pressure During
Long-Term Ouabain Infusion in
Long-Evans Rats
Jingli Wang, Aldo Tempini, Bruno Schnyder, and Jean-Pierre Montani
We tested whether ouabain, an inhibitor of the
sodium pump, can lead to chronic hypertension in
Long-Evans rats using sensitive 24-h measurements
of blood pressure....
- Furthermore, we also tested whether reduction in renal mass,
0895-7061/99/$20.00
PII S0895-7061(98)00250-7
424
WANG ET AL
a procedure that reduces the kidney’s ability to excrete
salt and water, can potentiate the pressor effect of
ouabain....
- Some authors have
reported that Long-Evans rats are less sensitive to
certain hypertensive agents, such as chronic cold exposure14 and sucrose loading.15 However, uninephrectomy increases blood pressure markedly during
sucrose loading.15 Furthermore, Long-Evans rats do
not seem to be resistant to mineralocorticoid-induced
hypertension, as mineralocorticoid administration
426
AJH–MARCH 1999 –VOL. 12, NO. 3
WANG ET AL
leads to similar increases in blood pressure in LongEvans rats, compared with Sprague Dawley rats.16
Nevertheless, we cannot exclude the possibility that
Long-Evans rats may have a different distribution of ␣
isoforms of the sodium pump in comparison to other
rat species....
|
In: British Journal of Nutrition, 2005, vol. 93, no. 4, p. 417-419
- These epidemiological associations
between midlife adiposity and later Parkinson’s disease, whose
cardinal signs are largely due to the loss of dopamine-producing
neurons in the substantia nigra area in the brain, together with clinical observations that obesity is associated with depletion of striatal
dopamine D2 receptor availability (Wang et al. 2001), suggest that
nigrostriatal system disorders are associated with both Parkinson’s
disease and obesity (Abbott et al. 2002)....
- Wang GJ, Volkow ND, Logan J, Pappas NR, Wong CT, Zhu W,
Netusil N & Fowler JS (2001) Brain dopamine and obesity....
|
In: Frontiers in Physiology, 2016, vol. 7, p. -
Obesity is associated with development and progression of chronic kidney disease (CKD). Recent evidence demonstrates that enhanced levels of the L- arginine:ureahydrolase, including the two isoenzymes arginase-I (Arg-I) and arginase- II (Arg-II) in vascular endothelial cells promote uncoupling of endothelial nitric oxide synthase (eNOS), leading to increased superoxide radical anion and...
- Commun. 233, 487–491. doi: 10.1006/bbrc.1997.6473
Jiang, T., Wang, Z., Proctor, G., Moskowitz, S., Liebman, S....
- Metab. 84, 243–251. doi: 10.1016/j.ymgme.
2004.11.004
Cui, W., Maimaitiyiming, H., Qi, X., Norman, H., and Wang, S. (2013)....
- Neurol. 47, 263–269. doi: 10.1016/
j.pediatrneurol.2012.06.012
Wang, C....
|
In: Integrative Physiology, 2016, p. 227
Uninephrectomy (UniNX) in rats on a fixed food intake leads to increased lipolysis and a low-grade inflammation with an increased subset of circulating cytokines. Because UniNX ablates renal nerves on the side of the removed kidney, we tested the contribution of unilateral renal denervation in the phenotype of UniNX. We compared Sham-operated controls, left nephrectomy (UniNX) and unilateral...
- ., Wang, X., Hoth, J....
- A., Zhu, L., Wang, F., et al. (2015)....
- Leong, J., Zhou, M., Jacob, A., and Wang, P. (2010)....
|
In: Cardiovascular Diabetology, 2014, vol. 13, no. 1, p. 113
Background Endothelial nitric oxide synthase (eNOS)-uncoupling links obesity-associated insulin resistance and type-II diabetes to the increased incidence of cardiovascular disease. Studies have indicated that increased arginase is involved in eNOS-uncoupling through competing with the substrate L-arginine. Given that arginase-II (Arg-II) exerts some of its biological functions through crosstalk...
- Sun Y, Ishibashi M, Seimon T, Lee M, Sharma SM, Fitzgerald KA, Samokhin AO, Wang YB, Sayers S, Aikawa M, Jerome WG, Ostrowski MC, Bromme D, Libby P, Tabas IA, Welch CL, Tall AR: Free cholesterol accumulation in macrophage membranes activates toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K....
- Ma XL, Kumar S, Gao F, Louden CS, Lopez BL, Christopher TA, Wang CL, Lee JC, Feuerstein GZ, Yue TL: Inhibition of p38 mitogen-activated protein kinase decreases cardiomyocyte apoptosis and improves cardiac function after myocardial ischemia and reperfusion....
|
In: Analytical Methods, 2013, vol. 5, p. 1155-1164
In order to study the roles of individual BAs and due to limited blood sample volumes available from experimental animals, improved methods for the simultaneous quantification of multiple BAs are needed. We developed and validated an ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method for the quantification of 24 BAs, including 11 unconjugated, 6...
- Wang, C....
- Wang, Z....
- Wang, W....
|
In: Frontiers in Vascular Physiology, 2012, vol. 3, p. 5
The global population aging is accelerating and age-associated diseases including cardiovascular diseases become more challenging. The underlying mechanisms of aging and age-associated cardiovascular dysfunction remain elusive. There are substantial evidences demonstrating a pivotal role of the mammalian target of rapamycin complex 1 (mTORC1) and its down-stream effector S6K1 signaling in...
- B., Wang, J., Hacker, T....
- A., Wang, T....
- M., and Wang, Y. (2010)....
|
In: European Journal of Clinical Nutrition, 2011, p. -
Waist circumference (WC) is a key variable to assess in health management as it is a proxy of abdominal fat mass and a surrogate marker of cardiometabolic disease risk, including the metabolic syndrome. Recently, a portable non-contact device calculating WC (ViScan) has been developed, which hence allows the tracking of WC independently of the inter-investigators error. We compared WC values...
- Discussion
WC is a ‘simple, inexpensive and reliable tool that should be included as part of physical examinations in the doctor’s office’ as pointed out by Wang (2003)....
- Wang J (2003)....
|
In: British Journal of Nutrition, 2007, vol. 93, p. 417-419
- These epidemiological associations
between midlife adiposity and later Parkinson’s disease, whose
cardinal signs are largely due to the loss of dopamine-producing
neurons in the substantia nigra area in the brain, together with clinical observations that obesity is associated with depletion of striatal
dopamine D2 receptor availability (Wang et al. 2001), suggest that
nigrostriatal system disorders are associated with both Parkinson’s
disease and obesity (Abbott et al. 2002)....
- Wang GJ, Volkow ND, Logan J, Pappas NR, Wong CT, Zhu W,
Netusil N & Fowler JS (2001) Brain dopamine and obesity....
|
