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Endothelial nitric oxide synthase genetransfer restores endothelium-dependentrelaxations and attenuates lesion formationin carotid arteries in apolipoproteinE-deficient mice

Mujynya-Ludunge, Kathi ; Viswambharan, Hema ; Driscoll, Robert ; Ming, Xiu-Fen ; von Segesser, Ludwig ; Kappenberger, Lukas ; Yang, Zhihong ; Vassalli, Giuseppe

In: Basic Research in Cardiology, 2005, vol. 100, no. 2, p. 102-111

Sirolimus increases tissue factor expression but not activity in cultured human vascular smooth muscle cells

Zhu, Shengsi ; Viswambharan, Hema ; Gajanayake, Thusitha ; Ming, Xiu-Fen ; Yang, Zhihong

In: BMC Cardiovascular Disorders, 2007, vol. 5, p. 22

Background Sirolimus-eluting stents (CYPHER stents) demonstrated remarkable efficacy in reducing restenosis rates in patients with coronary artery disease. There is a concern of sub-acute and late stent thrombosis. Tissue factor (TF) is critical in thrombosis. This study investigated the effect of sirolimus on TF expression and activity in cultured human vascular smooth muscle cells...

Mutation of the circadian clock gene Per2 alters vascular endothelial function

Viswambharan, Hema ; Carvas, João Miguel ; Antic, Vladan ; Marecic, Ana ; Jud, Corinne ; Zaugg, Christian E. ; Ming, Xiu-Fen ; Montani, Jean-Pierre ; Albrecht, Urs ; Yang, Zhihong

In: Circulation, 2007, vol. 115, p. 2188-2195

Background— The circadian clock regulates biological processes including cardiovascular function and metabolism. In the present study, we investigated the role of the circadian clock gene Period2 (Per2) in endothelial function in a mouse model. Methods and Results— Compared with the wild-type littermates, mice with Per2 mutation exhibited impaired...

Endothelial nitric oxide synthase gene transfer restores endothelium–dependent relaxations and attenuates lesion formation in carotid arteries in apolipoprotein E–deficient mice

Mujynya-Ludunge, Kathi ; Viswambharan, Hema ; Driscoll, Robert ; Ming, Xiu-Fen ; Segesser, Ludwig K. von ; Kappenberger, Lukas ; Yang, Zhihong ; Vassalli, Giuseppe

In: Basic Research in Cardiology, 2005, vol. 100(2), p. 102

Nitric oxide (NO) and monocyte chemoattractant protein–1 (MCP-1) exert partly opposing effects in vascular biology. NO plays pleiotropic vasoprotective roles including vasodilation and inhibition of platelet aggregation, smooth muscle cell proliferation, and endothelial monocyte adhesion, the last effect being mediated by MCP–1 downregulation. Early stages of arteriosclerosis are associated...

Thrombin Stimulates Human Endothelial Arginase Enzymatic Activity via RhoA/ROCK Pathway

Ming, Xiu-Fen ; Barandier, Christine ; Viswambharan, Hema ; Kwak, Brenda R. ; Mach, François ; Mazzolai, Lucia ; Hayoz, Daniel ; Ruffieux, Jean ; Rusconi, Sandro ; Montani, Jean-Pierre ; Yang, Zhihong

In: Circulation, 2004, vol. 110, p. 3708-3714

Background— Arginase competes with endothelial nitric oxide synthase (eNOS) for the substrate L-arginine and decreases NO production. This study investigated regulatory mechanisms of arginase activity in endothelial cells and its role in atherosclerosis. Methods and Results— In human endothelial cells isolated from umbilical veins, thrombin concentration- and time-dependently stimulated...