In: Experimental Neurology, 2004, vol. 186, no. 1, p. 78-88
A neuroprotective role for Ca²⁺-binding proteins in neurodegenerative conditions ranging from ischemia to Alzheimer's disease has been suggested in several studies. A key phenomenon in neurodegeneration is the Ca²⁺-mediated excitotoxicity brought about by the neurotransmitter glutamate. To evaluate the relative ability to resist excitotoxicity of neurons containing the slow-onset...
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Published in Experimental Neurology 186: 78-88, 2004
Ectopic parvalbumin expression in mouse forebrain neurons increases excitotoxic injury provoked by ibotenic acid injection into the striatum
Walter Maetzler, a Cordula Nitsch, a,* Kerstin Bendfeldt, a Peter Racay, b Florence Vollenweider, a and Beat Schwaller b
a
Section of Neuroanatomy, Institute of Anatomy, University of Basel, 4056 Basel, Switzerland b Division of Histology, Department of Medicine, University of Fribourg, Switzerland Received 20 June 2003; revised 11 September 2003; accepted 25 September 2003
Abstract A neuroprotective role for Ca2+-binding proteins in neurodegenerative conditions ranging from ischemia to Alzheimer’s disease has been suggested in several studies....
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