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Université de Fribourg

Microcalcification after excitotoxicity is enhanced in transgenic mice expressing parvalbumin in all neurones, may commence in neuronal mitochondria and undergoes structural modifications over time

Maetzler, W. ; Stünitz, H. ; Bendfeldt, Kerstin ; Vollenweider, F. ; Schwaller, Beat ; Nitsch, C.

In: Neuropathology and Applied Neurobiology, 2009, vol. 35, no. 2, p. 165 - 177

Aims: Parenchymal microcalcification in the brain coincides with neurodegenerative diseases, but is also frequently found in neurologically normal individuals. The origin and role of this process are still under debate. Parvalbumin (PV) is a protein acting as a Ca2+ buffer and Ca2+ shuttle towards intracellular Ca2+ sinks, like mitochondria and the endoplasmic reticulum. Constitutively, it is...

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1 Maetzler, Walter