In: Frontiers in Cellular Neuroscience, 2020, vol. 14, p. -
In neurodevelopmental disorders (NDDs) including autism spectrum disorder (ASD) and schizophrenia, impairment/malfunctioning of a subpopulation of interneurons expressing the calcium-binding protein parvalbumin (PV) –here termed Pvalb neurons– has gradually emerged as a possible cause. These neurons may represent a hub or point-of-convergence in the etiology of NDD. Increased oxidative...
- ., 2020), PV downregulation leads
to a compensatory/homeostatic upregulation of mitochondria
volume (Schwaller, 2020), while ectopic PV expression in all
neurons of Thy-PV transgenic mice decreases the mitochondria
volume evidenced in the striatum (Maetzler et al., 2004)....
- Maetzler, W., Nitsch, C., Bendfeldt, K., Racay, P., Vollenweider, F., and Schwaller,
B. (2004)....
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In: Journal of Chromatography B, 2018, vol. 1081–1082, p. 101–108
The plasma of Parkinson's disease (PD) patients may contain various altered metabolites associated with the risk or progression of the disease. Characterization of the abnormal metabolic pattern in PD plasma is therefore critical for the search for potential PD biomarkers. We collected blood plasma samples from PD patients and used an LC-MS based metabolomics approach to identify 17...
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In: Frontiers in Molecular Neuroscience, 2016, vol. 9, p. -
Autism spectrum disorders (ASD) comprise a number of heterogeneous neurodevelopmental diseases characterized by core behavioral symptoms in the domains of social interaction, language/communication and repetitive or stereotyped patterns of behavior. In utero exposure to valproic acid (VPA) has evolved as a highly recognized rodent ASD model due to the robust behavioral phenotype observed in...
- ., 2006; Maetzler
et al., 2009)....
- Neurobiol.
24, 285–300. doi: 10.5607/en.2015.24.4.285
Frontiers in Molecular Neuroscience | www.frontiersin.org
Maetzler, W., Stunitz, H., Bendfeldt, K., Vollenweider, F., Schwaller, B., and
Nitsch, C. (2009)....
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In: Biochimica et Biophysica Acta (BBA) - General Subjects, 2012, p. -
Background Cytosolic Ca² ⁺ buffers are members of the large family of Ca² ⁺-binding proteins and are essential components of the Ca² ⁺ signaling toolkit implicated in the precise regulation of intracellular Ca² ⁺ signals. Their physiological role in excitable cells has been investigated in vivo by analyzing the phenotype of mice either lacking one of the Ca² ⁺ buffers or...
- Maetzler, C....
- Maetzler, H....
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In: Hippocampus, 2012, vol. 22, p. 1107-1120
Although reductions in the expression of the calcium-buffering proteins calbindin D-28K (CB) and parvalbumin (PV) have been observed in the aging brain, it is unknown whether these changes contribute to age-related hippocampal dysfunction. To address this issue, we measured basal hippocampal metabolism and hippocampal structure across the lifespan of C57BL/6J, calbindin D-28k knockout (CBKO) and...
- ., 2000; Maetzler et al., 2004) and in vitro (D’Orlando et al., 2002)....
- Maetzler W, Nitsch C, Bendfeldt K, Racay P, Vollenweider F, Schwaller B. 2004....
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In: ACS Nano, 2009, vol. 3, no. 8, p. 2274–2280
At present, nanofilaments are not exclusively based on carbon atoms but can be produced from many inorganic materials in the form of nanotubes and nanowires. It is essential to systematically assess the acute toxicity of these newly synthesized materials since it cannot be predicted from the known toxicity of the same material in another form. Here, the cellular toxicity of TiO₂-based...
- Maetzler, W.; Nitsch, C.; Bendfeldt, K.; Raclay, P.; Vollenweider, F.; Schwaller, B....
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In: Neuropathology and Applied Neurobiology, 2009, vol. 35, no. 2, p. 165 - 177
Aims: Parenchymal microcalcification in the brain coincides with neurodegenerative diseases, but is also frequently found in neurologically normal individuals. The origin and role of this process are still under debate. Parvalbumin (PV) is a protein acting as a Ca2+ buffer and Ca2+ shuttle towards intracellular Ca2+ sinks, like mitochondria and the endoplasmic reticulum. Constitutively, it is...
- Maetzler*†, H....
- Neuroscience 2006; 142: 97–105 22 Maetzler W, Nitsch C, Bendfeldt K, Racay P, Vollenweider F, Schwaller B....
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In: Neuroscience, 2006, vol. 142, no. 1, p. 97-105
The Ca²⁺-binding proteins parvalbumin (PV) and calbindin D-28k (CB) are key players in the intracellular Ca²⁺-buffering in specific cells including neurons and have profound effects on spatiotemporal aspects of Ca²⁺ transients. The previously observed increase in mitochondrial volume density in fast-twitch muscle of PV−/− mice is viewed as a specific compensation mechanism to...
- Cerebella were dissected and a soluble and particulate fraction was prepared as described (Maetzler et al., 2004)....
- The ectopic expression of PV in transgenic mice (Van Den Bosch et al., 2002) decreases the mitochondria volume density in striatal neurons (Maetzler et al., 2004), a neuron population with a very low percentage of neurons with endogenous PV expression in WT mice....
- Maetzler W, Nitsch C, Bendfeldt K, Racay P, Vollenweider F, Schwaller B (2004) Ectopic parvalbumin expression in mouse forebrain neurons increases excitotoxic injury provoked by ibotenic acid injection into the striatum....
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In: FEBS Journal, 2006, vol. 273, no. 1, p. 96-108
- J Physiol 547, 649–663. 47 Maetzler W, Nitsch C, Bendfeldt K, Racay P, Vollenweider F & Schwaller B (2004) Ectopic parvalbumin expression in mouse forebrain neurons increases excitotoxic injury provoked by ibotenic acid injection into the striatum....
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In: Experimental Neurology, 2004, vol. 186, no. 1, p. 78-88
A neuroprotective role for Ca²⁺-binding proteins in neurodegenerative conditions ranging from ischemia to Alzheimer's disease has been suggested in several studies. A key phenomenon in neurodegeneration is the Ca²⁺-mediated excitotoxicity brought about by the neurotransmitter glutamate. To evaluate the relative ability to resist excitotoxicity of neurons containing the slow-onset...
- 1
Published in Experimental Neurology 186: 78-88, 2004
Ectopic parvalbumin expression in mouse forebrain neurons increases excitotoxic injury provoked by ibotenic acid injection into the striatum
Walter Maetzler, a Cordula Nitsch, a,* Kerstin Bendfeldt, a Peter Racay, b Florence Vollenweider, a and Beat Schwaller b
a
Section of Neuroanatomy, Institute of Anatomy, University of Basel, 4056 Basel, Switzerland b Division of Histology, Department of Medicine, University of Fribourg, Switzerland Received 20 June 2003; revised 11 September 2003; accepted 25 September 2003
Abstract A neuroprotective role for Ca2+-binding proteins in neurodegenerative conditions ranging from ischemia to Alzheimer’s disease has been suggested in several studies....
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