Université de Fribourg

From zero to six double bonds: phospholipid unsaturation and organelle function

Antonny, Bruno ; Vanni, Stefano ; Shindou, Hideo ; Thierry, Ferreira

In: Trends in Cell Biology, 2015, vol. 25, no. 7, p. 427–436

Cellular phospholipids (PLs) differ by the nature of their polar heads as well as by the length and unsaturation level of their fatty acyl chains. We discuss how the ratio between saturated, monounsaturated, and polyunsaturated PLs impacts on the functions of such organelles as the endoplasmic reticulum, synaptic vesicles, and photoreceptor discs. Recent experiments and simulations suggest...

Université de Fribourg

Feeding biomechanics suggests progressive correlation of skull architecture and neck evolution in turtles

Ferreira, Gabriel S. ; Lautenschlager, Stephan ; Evers, Serjoscha W. ; Pfaff, Cathrin ; Kriwet, Jürgen ; Raselli, Irena ; Werneburg, Ingmar

In: Scientific Reports, 2020, vol. 10, p. 5505

The origin of turtles is one of the most long-lasting debates in evolutionary research. During their evolution, a series of modifications changed their relatively kinetic and anapsid skull into an elongated akinetic structure with a unique pulley system redirecting jaw adductor musculature. These modifications were thought to be strongly correlated to functional adaptations, especially to bite...

Université de Fribourg

Conformational proofreading of distant 40S ribosomal subunit maturation events by a long-range communication mechanism

Mitterer, Valentin ; Shayan, Ramtin ; Ferreira-Cerca, Sébastien ; Murat, Guillaume ; Enne, Tanja ; Rinaldi, Dana ; Weigl, Sarah ; Omanic, Hajrija ; Gleizes, Pierre-Emmanuel ; Kressler, Dieter ; Plisson-Chastang, Celia ; Pertschy, Brigitte

In: Nature Communications, 2019, vol. 10, no. 1, p. 2754

Eukaryotic ribosomes are synthesized in a hierarchical process driven by a plethora of assembly factors, but how maturation events at physically distant sites on pre- ribosomes are coordinated is poorly understood. Using functional analyses and cryo- EM, we show that ribosomal protein Rps20 orchestrates communication between two multi-step maturation events across the pre-40S subunit. Our...

Université de Fribourg

A taxonomic reassessment of Piramys auffenbergi, a neglected turtle from the late Miocene of Piram Island, Gujarat, India

Ferreira, Gabriel S. ; Bandyopadhyay, Saswati ; Joyce, Walter G.

In: PeerJ, 2018, vol. 6, p. e5938

Piramys auffenbergi was described as an emydine turtle based on a well-preserved skull retrieved from late Miocene deposits exposed on Piram Island, India. The description and figures provided in the original publication are vague and do not support assignment to Emydinae. This taxon has mostly been ignored by subsequent authors.Material and Methods: We reexamine the holotype specimen,...