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    Université de Fribourg

    GUP1 of Saccharomyces cerevisiae Encodes an O-Acyltransferase Involved in Remodeling of the GPI Anchor

    Bosson, Régine ; Jaquenoud, Malika ; Conzelmann, Andreas

    In: Molecular Biology of the Cell, 2006, vol. 17, no. 6, p. 2636-2645

    The anchors of mature glycosylphosphatidylinositol (GPI)-anchored proteins of Saccharomyces cerevisiae contain either ceramide or diacylglycerol with a C26:0 fatty acid in the sn2 position. The primary GPI lipid added to newly synthesized proteins in the ER consists of diacylglycerol with conventional C16 and C18 fatty acids. Here we show that GUP1 is essential for the synthesis of...