Beaud Marie-Laure - Résultats de la recherche

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A case of polymicrogyria in macaque monkey: impact on anatomy and function of the motor system

Schmidlin, Eric ; Jouffrais, Christophe ; Freund, Patrick ; Wannier-Morino, Patrizia ; Beaud, Marie-Laure ; Rouiller, Eric M. ; Wannier, Thierry

In: BMC Neuroscience, 2009, vol. 10, p. 155

Background Polymicrogyria is a malformation of the cerebral cortex often resulting in epilepsy or mental retardation. It remains unclear whether this pathology affects the structure and function of the corticospinal (CS) system. The anatomy and histology of the brain of one macaque monkey exhibiting a spontaneous polymicrogyria (PMG monkey) were examined and compared to the brain of normal...

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Anti-Nogo-A antibody treatment does not prevent cell body shrinkage in the motor cortex in adult monkeys subjected to unilateral cervical cord lesion

Beaud, Marie-Laure ; Schmidlin, Eric ; Wannier, Thierry ; Freund, Patrick ; Bloch, Jocelyne ; Mir, Anis ; Schwab, Martin E. ; Rouiller, Eric M.

In: BMC Neuroscience, 2008, vol. 9, no. 1, p. 5

Background: After unilateral cervical cord lesion at the C7/C8 border interrupting the dorsolateral funiculus in adult monkeys, neutralization of Nogo-A using a specific monoclonal antibody promoted sprouting of corticospinal (CS) axons rostral and caudal to the lesion and, in parallel, improved functional recovery. In monkeys lesioned but not treated with the anti-Nogo-A antibody, the CS neurons...

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