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Effect of Inhibition of the Lysophosphatidic Acid Receptor 1 on Metastasis and Metastatic Dormancy in Breast Cancer

Marshall, Jean-Claude A. ; Collins, Joshua W. ; Nakayama, Joji ; Horak, Christine E. ; Liewehr, David J. ; Steinberg, Seth M. ; Albaugh, Mary ; Vidal-Vanaclocha, Fernando ; Palmieri, Diane ; Barbier, Maryse ; Murone, Maximilien ; Steeg, Patricia S.

In: Journal Of The National Cancer Institute, 2012, vol. 104, no. 17, p. 1306-1319

Weakening link to colorectal cancer ?

Barbier, Maryse ; Attoub, S. ; Calvez, Ronan ; Laffargue, Muriel ; Jarry, A. ; Mareel, M. ; Altruda, F. ; Gespach, C. ; Wu, D. ; Lu, B. ; Hirsch, E. ; Wymann, Matthias P.

In: Nature, 2001, vol. 413, p. 796

The catalytic α-subunit of the enzyme phosphatidylinositol-3-OH kinase (PI(3)Kα) relays signals from G- protein-coupled receptors at the cell membrane and mediates leukocyte responses to chemokines and chemoattractants1, 2, ³. Sasaki et al.⁴ report that mice that cannot produce PI(3)Kα have a high incidence of colorectal carcinomas, causing weight loss and...