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Université de Fribourg

Body composition phenotypes in pathways to obesity and the metabolic syndrome

Dulloo, Abdul G. ; Jacquet, Jean ; Solinas, Giovanni ; Montani, Jean-Pierre ; Schutz, Y.

In: International Journal of Obesity, 2010, vol. 34, p. S4–S17

Dynamic changes in body weight have long been recognized as important indicators of risk for debilitating diseases. While weight loss or impaired growth can lead to muscle wastage, as well as to susceptibility to infections and organ dysfunctions, the development of excess fat predisposes to type 2 diabetes and cardiovascular diseases, with insulin resistance as a central feature of the disease...

Université de Fribourg

Adipose tissue plasticity during catch-up fat driven by thrifty metabolism: relevance for muscle-adipose glucose redistribution during catch-up growth

Summermatter, Serge ; Marcelino, Helena ; Arsenijevic, Denis ; Buchala, Antony J. ; Aprikian, Olivier ; Assimacopoulos-Jeannet, Françoise ; Seydoux, Josiane ; Montani, Jean-Pierre ; Solinas, Giovanni ; Dulloo, Abdul G.

In: Diabetes, 2009, vol. 58, no. 10, p. 2228-2237

OBJECTIVE: Catch-up growth, a risk factor for later type 2 diabetes, is characterized by hyperinsulinemia, accelerated body-fat recovery (catch-up fat), and enhanced glucose utilization in adipose tissue. Our objective was to characterize the determinants of enhanced glucose utilization in adipose tissue during catch-up fat. RESEARCH DESIGN AND METHODS: White adipose tissue morphometry, lipogenic...

Université de Fribourg

Emerging roles of perivascular adipose tissue in regulation of vascular functions

Yang, Zhihong ; Montani, Jean-Pierre

In: Immunology, Endocrine & Metabolic Agents - Medicinal Chemistry, 2007, vol. 7, no. 2, p. 137-141

Clinical and experimental studies provide increasing evidence that obesity is a major cardiovascular risk factor and that the adipose tissue is not just for regulation of lipid and energy homeostasis. Accordingly, the endocrine secretion of adipose tissue is implicated in the pathogenesis of vascular diseases. Whilst the functions of visceral and subcutaneous adipose tissue are relatively...