In: Clinical Infectious Diseases, 2011, vol. 52, no. 8, p. 1058-1060
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In: Clinical Infectious Diseases, 1992, vol. 15, no. 3, p. 394-401
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In: Clinical Infectious Diseases, 2001, vol. 32, no. 4, p. 581-586
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In: Journal of Infectious Diseases, 1991, vol. 163, no. 4, p. 762-768
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In: Virology Journal, 2017, vol. 14, p. 8
Japanese encephalitis virus (JEV) is a neurotropic flavivirus causing mortality and morbidity in humans. Severe Japanese encephalitis cases display strong inflammatory responses in the central nervous system and an accumulation of viral particles in specific brain regions. Microglia cells are the unique brain-resident immune cell population with potent migratory functions and have been...
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In: Antimicrobial Agents and Chemotherapy, 2016, p. AAC.02934–15
Implant-associated infections (IAI) are a dreaded complication mainly caused by biofilm-forming staphylococci. Implant surfaces preventing microbial colonization would be desirable. We examined the preventive effect of a silver-coated titanium aluminium niobium (TiAlNb) alloy. The surface elicited a strong, inoculum-dependent activity against Staphylococcus (S.) epidermidis and S. aureus in an...
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In: Neurology, 2013, vol. 80, no. 6, p. 553–560
Objective: To assess the efficacy and safety of rivastigmine for the treatment of HIV-associated neurocognitive disorders (HAND) in a cohort of long-lasting aviremic HIV+ patients.Methods: Seventeen aviremic HIV+ patients with HAND were enrolled in a randomized, double-blind, placebo-controlled, crossover study to receive either oral rivastigmine (up to 12 mg/day for 20 weeks) followed by placebo...
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In: Molecular Ecology, 2013, vol. 22, no. 3, p. 842–855
Recent advances in population genomics have triggered great interest in the genomic landscape of divergence in taxa with ‘porous’ species boundaries. One important obstable of previous studies of this topic was the low genomic coverage achieved. This issue can now be overcome by the use of ‘next generation’ or short-read DNA-sequencing approaches capable of assaying many thousands of...
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In: Infection and Immunity, 2006, vol. 74, no. 7, p. 3890-3896
Bacterial meningitis is characterized by an inflammatory reaction to the invading pathogens that can ultimately lead to sensorineural hearing loss, permanent brain injury, or death. The matrix metalloproteinases (MMPs) and tumor necrosis factor alpha-converting enzyme (TACE) are key mediators that promote inflammation, blood-brain barrier disruption, and brain injury in bacterial meningitis....
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Thèse de doctorat : Université de Fribourg : 2000 ; Nr. 1328.
Human gene therapy can be defined as the directed transfer of exogenous genes or other nucleotide sequences into somatic cells, for the purpose of preventing, correcting or healing various diseases. This novel approach to the therapy of human disorders is based on the realization that many previous medical treatments have usually been directed at the consequences of causative defects or at...
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