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Université de Fribourg

TGFBI modulates tumour hypoxia and promotes breast cancer metastasis

Fico, Flavia ; Santamaria‐Martínez, Albert

In: Molecular Oncology, 2020, vol. 14, no. 12, p. 3198–3210

Breast cancer metastasis is a complex process that depends not only on intrinsic characteristics of metastatic stem cells, but also on the particular microenvironment that supports their growth and modulates the plasticity of the system. In search for microenvironmental factors supporting cancer stem cell (CSC) growth and tumour progression to metastasis, we here investigated the role of the...

Consortium of Swiss Academic Libraries

GAP-independent functions of DLC1 in metastasis

Barras, David ; Widmann, Christian

In: Cancer and Metastasis Reviews, 2014, vol. 33, no. 1, p. 87-100

Université de Fribourg

Characterization and in vivo validation of a three-dimensional multi-cellular culture model to study heterotypic interactions in colorectal cancer cell growth, invasion and metastasis

Cattin, Sarah ; Ramont, Laurent ; Rüegg, Curzio

In: Frontiers in Bioengineering and Biotechnology, 2018, vol. 6, p. -

Colorectal cancer (CRC) is the third cause of cancer-related mortality in industrialized countries. Local invasion and metastasis formation are events associated with poor prognosis for which today there are no effective therapeutic options. Invasion and metastasis are strongly modulated by cells of the tumor microenvironment (TME), in particular fibroblasts and endothelial cells. Unraveling...

Consortium of Swiss Academic Libraries

Selectins as mediators of lung metastasis

Läubli, H.

In: Cancer Microenvironment, 2010, vol. 3, no. 1, p. 97-105