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Università della Svizzera italiana

Structure and function analysis of an antibody recognizing all influenza A subtypes

Kallewaard, Nicole L. ; Corti, Davide ; Collins, Patrick J. ; Neu, Ursula ; McAuliffe, Josephine M. ; Benjamin, Ebony ; Wachter-Rosati, Leslie ; Palmer-Hill, Frances J. ; Yuan, Andy Q. ; Walker, Philip A. ; Vorlaender, Matthias K. ; Bianchi, Siro ; Guarino, Barbara ; De Marco, Anna ; Vanzetta, Fabrizia ; Agatic, Gloria ; Foglierini, Mathilde ; Pinna, Debora ; Fernandez-Rodriguez, Blanca ; Fruehwirth, Alexander ; Silacci, Chiara ; Ogrodowicz, Roksana W. ; Martin, Stephen R. ; Sallusto, Federica ; Suzich, JoAnn A. ; Lanzavecchia, Antonio ; Zhu, Qing ; Gamblin, Steven J. ; Skehel, John J.

In: Cell, 2016, vol. 166, no. 3, p. 596-608

Influenza virus remains a threat because of its ability to evade vaccine-induced immune responses due to antigenic drift. Here, we describe the isolation, evolution, and structure of a broad-spectrum human monoclonal antibody (mAb), MEDI8852, effectively reacting with all influenza A hemagglutinin (HA) subtypes. MEDI8852 uses the heavy-chain VH6-1 gene and has higher potency and breadth when...

Università della Svizzera italiana

The mediatization of the air : wireless telegraphy and the origins of a transnational space of communication, 1900-1910s

Rikitianskaia, Maria ; Balbi, Gabriele ; Lobinger, Katharina

In: Journal of communication, 2018, vol. 68, no. 4, p. 758–779

Airspace today is densely penetrated by Wi-Fi networks, GPS services, and broadcasting and mobile phone signals. This process, what we call the mediatization of the air, is not so new, as it began in the first two decades of the 20th century, with the advent of wireless telegraphy. Based on archival research, this paper shows that wireless telegraphy mediatized the air and made it a matter of...

Università della Svizzera italiana

The antibody response to Plasmodium falciparum : cues for vaccine design and the discovery of receptor-based antibodies

Tan, Joshua ; Piccoli, Luca ; Lanzavecchia, Antonio

In: Annual Review of Immunology

P. falciparum remains a serious public health problem and a continuous challenge for the immune system due to the complexity and diversity of the pathogen. Recent advances from several laboratories in the characterization of the antibody response to the parasite have led to the identification of critical targets for protection and revealed a new mechanism of diversification based on the...

Università della Svizzera italiana

Identification and structure of a multidonor class of head-directed influenza-neutralizing antibodies reveal the mechanism for its recurrent elicitation

Sao-Fong Cheung, Crystal ; Fruehwirth, Alexander ; Paparoditis, Philipp Carl Georg ; Shen, Chen-Hsiang ; Foglierini, Mathilde ; Joyce, M. Gordon ; Leung, Kwanyee ; Piccoli, Luca ; Rawi, Reda ; Silacci-Fregni, Chiara ; Tsybovsky, Yaroslav ; Verardi, Raffaello ; Wang, Lingshu ; Wang, Shuishu ; Yang, Eun Sung ; Zhang, Baoshan ; Zhang, Yi ; Chuang, Gwo-Yu ; Corti, Davide ; Mascola, John R. ; Shapiro, Lawrence ; Kwong, Peter D. ; Lanzavecchia, Antonio ; Zhou, Tongqing

In: Cell reports, 2020, vol. 32, no. 9, p. 12 p

Multidonor antibodies are of interest for vaccine design because they can in principle be elicited in the general population by a common set of immunogens. For influenza, multidonor antibodies have been observed against the hemagglutinin (HA) stem, but not the immunodominant HA head. Here, we identify and characterize a multidonor antibody class (LPAF-a class) targeting the HA head. This class...

Università della Svizzera italiana

Antibody-guided vaccine design : identification of protective epitopes

Lanzavecchia, Antonio ; Frühwirth, Alexander ; Perez, Laurent ; Corti, Davide

In: Current opinion in immunology, 2016, vol. 41, no. August, p. 62-67

In the last decade, progress in the analysis of the human immune response and in the isolation of human monoclonal antibodies have provided an innovative approach to the identification of protective antigens which are the basis for the design of vaccines capable of eliciting effective B-cell immunity. In this review we illustrate, with relevant examples, the power of this approach that can...

Università della Svizzera italiana

A LAIR-1 insertion creates broadly reactive antibodies against malaria variant antigens

Tan, Joshua ; Pieper, Kathrin ; Piccoli, Luca ; Abdi, Abdirahman ; Tully, Claire Maria ; Foglierini Perez, Mathilde ; Geiger, Roger ; Jarrossay, David ; Maina Ndungu, Francis ; Wambua, Juliana ; Bejon, Philip ; Silacci Fregni, Chiara : Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland ; Fernandez-Rodriguez, Blanca ; Barbieri, Sonia ; Bianchi, Siro ; Marsh, Kevin ; Thathy, Vandana ; Corti, Davide ; Sallusto, Federica ; Bull, Peter ; Lanzavecchia, Antonio

In: Nature, 2016, vol. 529, p. 25 p

Plasmodium falciparum antigens expressed on the surface of infected erythrocytes are important targets of naturally acquired immunity against malaria, but their high number and variability provide the pathogen with a powerful means of escape from host antibodies1,2,3,4. Although broadly reactive antibodies against these antigens could be useful as therapeutics and in vaccine design, their...

Università della Svizzera italiana

Fighting the spread of Covid-19 : was the Swiss lockdown worth it?

Gatti, Nicolò ; Retali, Beatrice

The implementation of a lockdown to control the Covid-19 pandemic has led to a strong debate in several countries. This makes it crucial to shed light on the actual benefits of such kind of policy. To this purpose, we focus on the Swiss lockdown during the first wave of Covid-19 infections and estimate the number of potentially saved lives. To predict the number of deaths in absence of any...

Università della Svizzera italiana

Robots and nonparticipation in the US : where have all the workers gone?

Lerch, Benjamin

I analyze the impact of one of the leading automation technologies of the last decades – industrial robots – on the declining labor force participation in the US. Exploiting exogenous variation in the adoption of robots across local labor markets and over time, I find that, on average, one additional robot drives two workers out of the labor force. The massive increase in robot adoption...

Haute école de gestion de Genève

Leading Millennials : what motivates and retains a labeled generation ?

Sukariyeh, Jude ; Connerton, Timothy (Dir.)

Mémoire de bachelor : Haute école de gestion de Genève, 2020 ; TDIBM 80.

This research aims at understanding why are Millennials’ a labeled generation, what are their characteristics and how can Leaders motivate as well as retain them. To do so, theories and studies are explored to see to which extend theory confirms what is observed in practice. The literature review attempts to share a storyline with the readers. The research covers various topics, from the...

Haute école de gestion de Genève

How to optimize the Talent Acquisition Strategy and Recruitment Process in Swiss startups and young ventures to build a winning team ?

Krenzi, Laurent ; Hafil, Ansar (Dir.)

Mémoire de bachelor : Haute école de gestion de Genève, 2020 ; TDIBM 86.

Recruiting has been shown to be a very important factor of a company’s development and success, it also been highlighted to be a key source of competitive power and key component to build a winning team. Researches state that many young ventures have difficulty to recruit properly. Following a combination of weak recruitment capabilities with limited access to the right talents, the...