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Université de Fribourg

Positive humor in couples as interpersonal emotion regulation : A dyadic study in everyday life on the mediating role of psychological intimacy

Horn, Andrea B. ; Samson, Andrea C. ; Debrot, Anik ; Perrez, Mainrad

In: Journal of Social and Personal Relationships, 2019, vol. 36, no. 8, p. 2376-2396

The aim of this study was to investigate daily positive humor in couples as an interpersonal emotion regulation strategy. Associated changes in psychological intimacy were tested as a possible socio- affective pathway of emotion regulation that mediates the effects of couple humor on changes in individual momentary affect. Within a dyadic ambulatory assessment framework, 102 couples...

Université de Fribourg

A standard numbering scheme for class c β-lactamases

Mack, Andrew R. ; Barnes, Melissa D. ; Taracila, Magdalena A. ; Hujer, Andrea M. ; Hujer, Kristine M. ; Cabot, Gabriel ; Feldgarden, Michael ; Haft, Daniel H. ; Klimke, William ; Akker, Focco van den ; Vila, Alejandro J. ; Smania, Andrea ; Haider, Shozeb ; Papp-Wallace, Krisztina M. ; Bradford, Patricia A. ; Rossolini, Gian Maria ; Docquier, Jean-Denis ; Frère, Jean-Marie ; Galleni, Moreno ; Hanson, Nancy D. ; Oliver, Antonio ; Plésiatyz, Patrick ; Poirel, Laurent ; Nordmann, Patrice ; Palzkill, Timothy G. ; Jacoby, George A. ; Bush, Karen ; Bonomo, Robert A.

In: Antimicrobial Agents and Chemotherapy, 2020, vol. 64, no. 3, p. -

Unlike for classes A and B, a standardized amino acid numbering scheme has not been proposed for the class C (AmpC) β-lactamases, which complicates communication in the field. Here, we propose a scheme developed through a collaborative approach that considers both sequence and structure, preserves traditional numbering of catalytically important residues (Ser64, Lys67, Tyr150, and Lys315),...

Université de Fribourg

Corona Immunitas: study protocol of a nationwide program of SARS-CoV-2 seroprevalence and seroepidemiologic studies in Switzerland

West, Erin A. ; Anker, Daniela ; Amati, Rebecca ; Richard, Aude ; Wisniak, Ania ; Butty, Audrey ; Albanese, Emiliano ; Bochud, Murielle ; Chiolero, Arnaud ; Crivelli, Luca ; Cullati, Stéphane ; d'Acremont, Valérie ; Epure, Adina Mihaela ; Fehr, Jan ; Flahault, Antoine ; Fornerod, Luc ; Frank, Irène ; Frei, Anja ; Michel, Gisela ; Gonseth, Semira ; Guessous, Idris ; Imboden, Medea ; Kahlert, Christian R. ; Kaufmann, Laurent ; Kohler, Philipp ; Mösli, Nicolai ; Paris, Daniel ; Probst-Hensch, Nicole ; Rodondi, Nicolas ; Stringhini, Silvia ; Vermes, Thomas ; Vollrath, Fabian ; the Corona Immunitas Research Group

In: International Journal of Public Health, 2020, vol. 65, no. 9, p. 1529–1548

Objectives Seroprevalence studies to assess the spread of SARS-CoV-2 infection in the general population and subgroups are key for evaluating mitigation and vaccination policies and for understanding the spread of the disease both on the national level and for comparison with the international community. Methods Corona Immunitas is a research program of coordinated, population-based,...

Université de Fribourg

Optogenetic stimulation of basal forebrain parvalbumin neurons activates the default mode network and associated behaviors

Lozano-Montes, Laura ; Dimanico, Marta ; Mazloum, Reza ; Li, Wenxue ; Nair, Jayakrishnan ; Kintscher, Michael ; Schneggenburger, Ralf ; Harvey, Michael ; Rainer, Gregor

In: Cell Reports, 2020, vol. 33, no. 6, p. 108359

Activation of the basal forebrain (BF) has been associated with increased attention, arousal, and a heightened cortical representation of the external world. In addition, BF has been implicated in the regulation of the default mode network (DMN) and associated behaviors. Here, we provide causal evidence for a role of BF in DMN regulation, highlighting a prominent role of parvalbumin (PV)...

Université de Fribourg

Epilepsy-associated neurocognitive disorders (EAND) in an onchocerciasis-endemic rural community in Cameroon: A population-based case–control study

K.Njamnshi, Alfred ; Chokote, Eric-Samuel ; Ngarka, Leonard ; Nfor, Leonard N. ; Tabaha, Earnest N. ; Basseguin Atchou, Jonas G. ; Angwaforbe, Samuel A. ; Nkouonlack, Cyrille ; Mengnjo, Michel K. ; Njamnshi, Wepnyu Y. ; Demaa, Fidèle ; Tataha, Godwin Y. ; Zoung-KanyiBissek, Anne-Cecile ; Annoni, Jean-Marie ; Ruffieux, Nicolas

In: Epilepsy & Behavior, 2020, vol. 112, no. 2020-, p. 107437

Epilepsy affects at least 50 million individuals worldwide, especially in sub-Saharan Africa (sSA). Cognitive impairment is common in people with epilepsy (PWE) yet, little is known on the burden of cognitive impairment in people with epilepsy in sSA. This study was thus designed to assess cognitive impairment in PWE or epilepsy- associated neurocognitive disorders (EAND) in a rural population...

Université de Fribourg

Distal and proximal hypoxia response elements cooperate to regulate organ-specific erythropoietin gene expression

Orlando, Ilaria M. C. ; Lafleur, Véronique N. ; Storti, Federica ; Spielmann, Patrick ; Crowther, Lisa ; Santambrogio, Sara ; Schödel, Johannes ; Hoogewijs, David ; Mole, David R. ; Wenger, Roland H.

In: Haematologica, 2019, vol. 105, no. 12, p. 2774–2784

While it is well-established that distal hypoxia response elements (HREs) regulate hypoxia-inducible factor (HIF) target genes such as erythropoietin (Epo), an interplay between multiple distal and proximal (promoter) HREs has not been described so far. Hepatic Epo expression is regulated by a HRE located downstream of the EPO gene, but this 3' HRE is dispensable for renal EPO gene...

Université de Fribourg

Gene expression analysis in the mouse brainstem identifies Cart and Nesfatin as neuropeptides coexpressed in the Calbindin-positive neurons of the Nucleus papilio

Girard, Franck ; von Siebenthal, Michelle ; Davis, Fred P. ; Celio, Marco R.

In: Sleep, 2020, vol. 43, no. 2020-11, p. zsaa085

Study Objectives: The brainstem contains several neuronal populations, heterogeneous in terms of neurotransmitter/neuropeptide content, which are important for controlling various aspects of the rapid eye movement (REM) phase of sleep. Among these populations are the Calbindin (Calb)-immunoreactive NPCalb neurons, located in the Nucleus papilio, within the dorsal paragigantocellular nucleus...

Université de Fribourg

Skin proteomics – analysis of the extracellular matrix in health and disease

Dengjel, Jörn ; Bruckner-Tuderman, Leena ; Nyström, Alexander

In: Expert Review of Proteomics, 2020, vol. 17, no. 5, p. 377–391

Introduction The skin protects the human body from external insults and regulates water and temperature homeostasis. A highly developed extracellular matrix (ECM) supports the skin and instructs its cell functions. Reduced functionality of the ECM is often associated with skin diseases that cause physical impairment and also have implications on social interactions and quality of life of...

Haute école de gestion de Genève

Implications for shipowners and charterers of the IMO 2020 low sulphur regulations

Marsolais, Jerome ; Reboulleau, Jerome (Dir.)

Mémoire de bachelor : Haute école de gestion de Genève, 2020 ; TDIBM 78.

The objective of this thesis is to evaluate the effects of the implementation of the International Maritime Organization (IMO) 2020 regulations of low Sulphur emissions on the shipping industry. The new amendments to MARPOL Annex VI that came into force on January 1st, has generated as great deal of anticipation and uncertainty for shipowners and market participants. The choices that...