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Université de Fribourg

Dopamine transporter (DAT) knockdown in the nucleus accumbens improves anxiety- and depression-related behaviors in adult mice

Bahi, Amine ; Dreyer, Jean-Luc

In: Behavioural Brain Research, 2019, vol. 359, p. 104–115

Many epidemiological and clinical studies have demonstrated a strong comorbidity between anxiety and depression, and a number of experimental studies indicates that the dopamine transporter (DAT) is involved in the pathophysiology of anxiety and depression. However, studies using laboratory animals have yielded inconclusive results. The aim of the present study was to examine the effects of...

Université de Fribourg

Hematological analysis of the ascidian Botrylloides leachii (Savigny, 1816) during whole-body regeneration

Blanchoud, Simon ; Zondag, Lisa ; Lamare, Miles D. ; Wilson, Megan J.

In: The Biological Bulletin, 2017, vol. 232, no. 3, p. 143–157

Whole-body regeneration (WBR)—the formation of an entire adult from only a small fragment of its own tissue—is extremely rare among chordates. Exceptionally, in the colonial ascidian Botrylloides leachii (Savigny, 1816) a fully functional adult is formed from their common vascular system after ablation of all adults from the colony in just 10 d, thanks to their high blastogenetic...

Université de Fribourg

Lentiviral-mediated let-7d microRNA overexpression induced anxiolytic- and anti-depressant-like behaviors and impaired dopamine D3 receptor expression

Bahi, Amine ; Dreyer, Jean-Luc

In: European Neuropsychopharmacology, 2018, vol. 28, no. 12, p. 1394–1404

Generalized anxiety and major depression disorders (MDD) are severe debilitating mood disorders whose etiology are not fully understood, but growing evidence indicates that microRNAs (miRNAs) might play a key role in their neuropathophysiological mechanisms. In the current study, we investigate the role of Lethal-7 (let-7d) miRNA, and its direct target dopamine D3 receptor (D3R) gain-of-...

Université de Fribourg

Protein amyloid fibrils as template for the synthesis of silica nanofibers, and their use to prepare superhydrophobic, lotus-like surfaces

Rima, Simonetta ; Lattuada, Marco

In: Small, 2018, vol. 14, no. 46, p. 1802854

In this work, amyloid fibrils are used as a template for the preparation of long silica fibers, with a variety of aspect ratios and surface roughness. Starting with β‐ lactoglobulin fibrils with typical diameters of about 20 nm and a length of several micrometers, two different strategies are followed to grow silica: either in water at acidic pH values, or in ethanol–water mixtures under...

Université de Fribourg

Solid-state structure and anti­microbial and cytotoxicity studies of a cucurbit[6]uril-like Cu6L4 constructed from 3,5-bis­[(1H-tetra­zol-5-yl)meth­yl]-4H-1,2,4-triazol-4-amine

Vasylevskyi, Serhii ; Holzheu, Anja ; Fromm, Katharina M.

In: Acta Crystallographica Section C: Structural Chemistry, 2018, vol. 74, no. 11, p. 1413–1419

3,5-Bis[(1H-tetra­zol-5-yl)meth­yl]-4H-1,2,4-triazol-4-amine (H2L) associates under deprotonation with CuSO4 in aqueous medium to form a new waisted barrel-shaped M6L4 cluster, namely hexa­aqua­tetra­kis­{μ4-3,5-bis­[(1H-tetra­zol-5-yl)meth­yl]-4H-1,2,4- triazol-4-amine}-μ4-sulfato-hexa­copper(II) sulfate hydrate, [Cu6(SO4) (C6H6N12)4(H2O)6]SO4·nH2O (n = ∼23) (1). Cluster 1...

Université de Fribourg

Detection of colistin-resistant Gram-negative rods by using the SuperPolymyxin medium

Jayol, Aurélie ; Poirel, Laurent ; André, Catherine ; Dubois, Véronique ; Nordmann, Patrice

In: Diagnostic Microbiology and Infectious Disease, 2018, vol. 92, no. 2, p. 95–101

The commercial SuperPolymyxin medium (ELITechGroup, Puteaux, France), currently licensed in Europe, is aimed to screen for either intrinsic or acquired colistin resistance in Gram negatives. It was tested for screening colistin-resistant Gram- negative rods from bacterial cultures of 145 colistin-resistant and 86 colistin- susceptible Gram-negative rods isolates. It exhibited a sensitivity and...

Université de Fribourg

Dysregulation of parvalbumin expression in the Cntnap2−/− mouse model of autism spectrum disorder

Lauber, Emanuel ; Filice, Federica ; Schwaller, Beat

In: Frontiers in Molecular Neuroscience, 2018, vol. 11, p. -

Due to the complex and heterogeneous etiology of autism spectrum disorder (ASD), identification of convergent pathways and/or common molecular endpoints in the pathophysiological processes of ASD development are highly needed in order to facilitate treatment approaches targeted at the core symptoms. We recently reported on decreased expression of the Ca2+-binding protein parvalbumin (PV) in...

Université de Fribourg

A human gonadal cell model from induced pluripotent stem cells

Gutiérrez, Daniel Rodríguez ; Eid, Wassim ; Biason-Lauber, Anna

In: Frontiers in Genetics, 2018, vol. 9, p. -

Sertoli cells are main players in the male gonads development and their study may shed light on 46,XY disorders of sex development (DSD). Mature primary Sertoli cells are incapable of proliferating in prolonged in vitro cultures and the available Sertoli cell models have several limitations since they derive from mouse or human cancer tissues. We differentiated human fibroblasts (HFs)-derived...

Université de Neuchâtel

The conversion of family farms in Southland" : A case study for “rural futures: building adaptive management capability to deliver sustainable pastoral farm systems”

Forney, Jérémie

Project description This research on farm conversions in Southland is funded by the Swiss National Science Foundation as an independent project. It has joined the RURAL FUTURES project (a MSI funded programme) to serve as a case study of the social aspects involved in farmers’ decision-making. The aim of the research is to identify non-economic motivators to farm conversion....

Université de Fribourg

Colloidal fibers as structurant for worm-like micellar solutions

Zanchetta, Giuliano ; Mirzaagha, Shadi ; Guida, Vincenzo ; Zonfrilli, Fabio ; Caggioni, Marco ; Grizzuti, Nino ; Pasquino, Rossana ; Trappe, Veronique

In: Colloid and Polymer Science, 2018, vol. 296, no. 8, p. 1379–1385

We investigate the rheological properties of a simplified version of a liquid detergent composed of an aqueous solution of the linear alkylbenzene sulphonate (LAS) surfactant, in which a small amount of fibers made of hydrogenated castor oil (HCO) is dispersed. At the concentration typically used in detergents, LAS is in a worm-like micellar phase exhibiting a Maxwellian behavior. The...