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Consortium of Swiss Academic Libraries

A novel animal model for external anal sphincter insufficiency

Brügger, Lukas ; Inglin, Roman ; Candinas, Daniel ; Sulser, Tullio ; Eberli, Daniel

In: International Journal of Colorectal Disease, 2014, vol. 29, no. 11, p. 1385-1392

Université de Fribourg

Secretome of adipose-derived mesenchymal stem cells promotes skeletal muscle regeneration through synergistic action of extracellular vesicle cargo and soluble proteins

Mitchell, Robert ; Mellows, Ben ; Sheard, Jonathan ; Antonioli, Manuela ; Kretz, Oliver ; Chambers, David ; Zeuner, Marie-Theres ; Tomkins, James E. ; Denecke, Bernd ; Musante, Luca ; Joch, Barbara ; Debacq-Chainiaux, Florence ; Holthofer, Harry ; Ray, Steve ; Huber, Tobias B. ; Dengjel, Joern ; De Coppi, Paolo ; Widera, Darius ; Patel, Ketan

In: Stem Cell Research & Therapy, 2019, vol. 10, no. 1, p. 116

The mechanisms underpinning the regenerative capabilities of mesenchymal stem cells (MSC) were originally thought to reside in their ability to recognise damaged tissue and to differentiate into specific cell types that would replace defective cells. However, recent work has shown that molecules produced by MSCs (secretome), particularly those packaged in extracellular vesicles (EVs), rather...